III - innate immunity Flashcards
in myeloid lineage outline the path to a basophil
haematopoietic stem cell
myeloid lineage
neutrophil
basophil
what is a path to a macrophage/dendritic cells
haematopoietic stem cell
myeloid lineage
monocytes
dendrites/macrophages
in myeloid lineage what comes after myeloid lineage cell besides neutrophil or monocytes
eosinophil
features of innate immunity
non-specific - general
immediate response
no immunological memory
what does humoral immunity consist of
pattern receptors
complement
enzymes
cytokines
what does cellular immunity consist of
phagocytes
natural killer cell
what is awareness in immediate response
detection of pathogens to signal their presence
what are the features of an immediate response
resident tissue factors
recruitment of cells from the blood
chemical signals generated
what are the features of inflammation
tissue injury - release of chemical signals - histamine
dilation and increased leakiness of local blood vessels - migration of phagocytes to the area
phagocytes consume pathogens and debris - tissue heals
name a pathogen recognition receptor (PRR)
TLK4
name a pathogen associated molecular pattern (PAMP)
LPS from bacteria
functions of interferons and cytokines
signalling neighbouring cells to setup barriers
signal infected cells to die
recruits WBC for adaptive immunity
outline TCR signalling that leads to expression of inflammatory genes
ligand - CP5
receptor - TLR4
MyD88
NF-kB
expression of inflammatory genes
outline TCR signalling via TRIF and what does it lead to
CP5
TLR4
TRIF
IRF’s
expression of type 1 interferon genes
what is MyD88 and what does it do
universal TLR adapter
interacts via TLR domain
promotes association of IRAK1/4 kinase
