IBD

Question 0

CBC findings for UC

Answer 0

HB down
WBC up
ESR up
C-Reactive Protein up
Albumin down

P-ANCA +
ASCA (anti-saccharomyces cerevisiae) - (positive in crohn’s)

Question 1

Non-caseating granulomas seen in CD or UC?

Answer 1

Crohn’s

Question 2

Why are out-break patients and severe patients of UC forbidden from radiography?

Answer 2

can cause toxic megacolon

Question 3

Clinical manifestations of CD:
location of pain
appearance of stool

Answer 3

Lower right quadrant (terminal ilium)
aggravated after dinner
no rectal bleeding, lots of mucopus

Question 4

Linear ulceration seen in

Answer 4

Crohn’s disease (early stages)

Question 5

Differential diagnosis of UC

Answer 5

Crohn's
chronic dysentery
amebiasis
schistosome
colon cancer
IBS

Question 6

Differential diagnosis for CD

Answer 6

Intestine TB (check PPD)
UC
Intestinal lymphoma
Acute appendicitis

Question 7

Fistulas more likely to form in

Answer 7

CD

Question 8

Extraintestinal manifestations of IBD

Answer 8

digital clubbing
erythema nodulosum
arthritis
sclerosing cholangitis

Question 9

Sulfasalazine MOA

Answer 9

Colonic bacteria converts to the active 5-ASA (5-aminosalicylic acid)

affects metabolism of arachidonic acid and inhibit synthesis of prostaglandins

Cleans up oxygen free radicals, relieves inflammation

Question 10

Antibiotics to treat CD

Answer 10

Metronidazole

Ciprofloxacin

Question 11

Infliximab use, MoA

Answer 11

CD
Ab directed against TNFa,
for IBD that is refractory to steroid therapy

***Can reactivate TB