asthma

Question 0

What is Atopy?

Answer 0

Genetic predisposition to develop IgE in response to environmental allergens

Question 1

Cells involved in asthma reaction

Answer 1

allergens activate Mast Cells and Dendritic Cells and epithelial cells
Dendritic cells activate TH2
TH2 activates mast and B Cells and Eosinophils

Question 2

Diagnosis of asthma

Answer 2

A history of symptoms (more than one type of symptom, occurs variably, worse at night, triggered by exercise, allergens, worse with infection)

FEV1/FVC test
Bronchodilator reversibility test

Question 3

Positive Bronchodilator Reversibility Test values

Answer 3

Increase in FEV1 of 200mL and 12% above pre-bronchodilator FEV1 value

Question 4

PEF?

Answer 4

Peak expiratory flow: indicates force of respiratory muscle and airway obstruction.

PEF variability = (max-min)/.5*(max+min)x100%
>20% = asthma

Question 5

Asthma drug administration devices

Answer 5

pMDI = pressurized metered-dose inhalers
DPI = dry powder inhalers
Nebulizers
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