I wanna kms Flashcards
What is an allergen?
An allergen is a typically harmless substance that triggers an exaggerated immune response in some individuals.
Common allergens include pollen, dust mites, and certain foods.
How is an allergen different from an antigen?
An antigen is any substance that triggers an immune response, but allergens specifically cause hypersensitivity reactions.
While all allergens are antigens, not all antigens are allergens.
What role do mast cells play in allergies?
Mast cells release histamine and other chemicals during an allergic reaction.
Histamine release leads to symptoms such as itching and swelling.
What do IgE antibodies do in allergic reactions?
IgE antibodies bind to allergens and trigger mast cell activation.
This activation leads to the release of inflammatory mediators.
What is an anaphylactic reaction?
A severe, life-threatening allergic reaction causing airway constriction, a drop in blood pressure, and shock.
What is the function of antihistamines?
Antihistamines block histamine receptors.
What does epinephrine (EpiPen) do?
Epinephrine counteracts anaphylaxis by relaxing airway muscles and constricting blood vessels.
What is an autoimmune disease?
A condition where the immune system mistakenly attacks the body’s own tissues.
How does the body carry out an autoimmune attack in Multiple Sclerosis (MS)?
T cells target myelin, the protective sheath around nerve fibers, leading to nerve damage.
Which immune cells are abnormally active in MS?
T cells, B cells, and macrophages.
What are common symptoms of Multiple Sclerosis?
Muscle weakness, vision loss, numbness, and coordination issues.
What are Disease-Modifying Therapies (DMTs) for MS?
Treatments that slow progression, such as interferons.
What is rheumatoid arthritis?
An autoimmune disease where the immune system attacks joint linings, causing inflammation, pain, and damage.
What immune cells are involved in rheumatoid arthritis?
T cells, B cells, and inflammatory cytokines.
List symptoms of rheumatoid arthritis.
- Swollen joints
- Painful joints
- Stiffness
What are DMARDs?
Disease-Modifying Antirheumatic Drugs that slow joint damage.
What is HIV?
A virus that targets the immune system, leading to AIDS, a condition of severe immune suppression.
Which immune cell does HIV target?
CD4+ T cells.
What are the implications for HIV patients?
They become vulnerable to opportunistic infections and cancers.
What is antiretroviral therapy (ART)?
A treatment that suppresses viral replication in HIV patients.
What are MHC proteins?
Proteins that recognize body cells.
What are HLA proteins?
Proteins that recognize macrophages and B cells.
What are the types of transplants?
- Organ (e.g., kidney, liver)
- Tissue
- Bone marrow
What occurs during transplant rejection?
The immune system attacks the transplanted tissue.