Hypothalamus Flashcards
3 Zones
Medial
Lateral
Periventricular
6 Inputs for Hypothal
Nuclei of solitary tract: visceral sensory info
Retina: circadian rhythm
Reticular formation: inputs from SC
Limbic/olfactory: signals reg eating and repro
Circumventricular organs that lack BBB
Intrinsic thermo/osmo/chemoRs
2 Principal Outputs of Hypothal
Neuronal connections to other parts of brain
Hormones and releasing factors from neurons mainly in perivent zone
Diff b/w Thalamus/Hypothal
Thal has direct areas which shuttle specific things to specific places, hypothal integrates a bunch of shit and then releases shit with widespread effects
Magnocellular Neurosecretory Cells
Large neurons from perivent region that go to post pit and release ADH/vasopressin and oxytocin into circulation. Dendrites also release oxytocin for CNS communication
Parvocellular Neurosecretory Cells
Smaller neurons that secrete RHs into bloodstream that feeds/controls ant pit
Feeding/Satiety Geography in Hypothal
Lateral feeding centers and medial satiety centers
Leptin
Fat storage cell-produced hormone that slowly builds to decrease appetite (not immediate neg feedback) by inhibiting NPY-secreting cells in hypothal
Arcuate Nucleus
Fulcrum for feeding-satiety balance, contains neurons that respond to peptide hormones that control appetite
Ghrelin
Neuropeptide released from GI (stomach) just prior to meal to stimulate feeding
PYY
Peptide released during feeding that promotes satiety