hyperlipidemia and GI for final

Question 1

Statins

Answer 1

• LOWERS LDL
• HMG CoA reductase inhibitors
• increase uptake of LDL from blood
• inhibit cholesterol production

Question 2

Niacin

Answer 2

• RAISES HDL
• inhibit lipolysis in adipose tissue
• > doesn’t create FFAs

Question 3

Fibrates

Answer 3

• increases expression of lipoprotein lipase

- raises HDL

Question 4

Bile Acid binding resins

Answer 4

• bind with bile salts

- prevent uptake of LDL -> excreted

Question 5

Cholesterol absorption inhibitors

Answer 5

-inhibit intestinal absorption of LDL

Question 6

GI antimicrobial agents

Answer 6

-treat H. Pylori infection

Question 7

H2 blockers

Answer 7

• block H2 receptors -> prevent gastric acid secretion

- treat ulcers and GERD

Question 8

Proton pump inhibitors

Answer 8

• Inactivate H+/K+ pumps of parietal cells

- Lowers H+ ions in gastric lumen

Question 9

Prostaglandins

Answer 9

-stimulate release of mucus and bicarb to neutralize gastric acid
(least effective)

Question 10

Antacids

Answer 10

• weak bases

- neutralize gastric acid to water and salt

Question 11

Mucosal protective agents

Answer 11

• enhance mucosal layer protection

- reduce inflammation and promote healing of ulcers