Hyperlipidemia Flashcards
1
Q
Hypercholesterolemia
A
- elevated total cholesterol
- elevated LDL
- normal triglycerides
2
Q
Hypertriglyceridemia
A
-high plasma triglycerides
3
Q
Mixed Hyperlipidemia
A
- elevated total cholesterol
- elevated LDL
- elevated triglycerides
4
Q
LDL Goals
A
- 1 or less risk factors - under 160
- 2 or more risk factors - under 130
- with CHD - under 100
5
Q
ideal LDL, cholesterol, triglycerides
A
- LDL - under 100
- total cholesterol - under 200
- Triglycerides - under 150
6
Q
HMG CoA reductase inhibitors
A
- statins
- first line of treatment
- inhibit enzyme in liver -> inhibit VLDL release
- reduce circulating LDL 10-70%
7
Q
atorvostatin (lipitor)
A
- 40-50% reduction in LDL
- half-life of 14 hours
- 10-80 mg
- interacts with coumadin
8
Q
HMG CoA reductase inhibitors effects
A
4 - LDL
2 - HDL
2 - Triglycerides
9
Q
Niacin (nicotinic acid)
A
- Increases HDL - lowers triglycerides
- 10 - 20% reduction in HDL
10
Q
Niacin effects
A
2 - LDL
4 - HDL
3 - Triglycerides
11
Q
Fibrates
A
- Lowers triglycerides - increased lipoprotein lipase
- Increases HDL - increased expression of APO
12
Q
Fibrate effects
A
1 - LDL
3 - HDL
4 - Triglycerides
13
Q
Bile Acid Resins
A
- Bind with bile salts and precipitate
- Prevent LDL reabsorption from intestine to liver
14
Q
Ezetimibe
A
- cholesterol absorption inhibitor
- reduced stored cholesterol in liver
15
Q
Chylomicrons
A
- 99% cholesterol
- formed in intestine
- transport cholesterol and triglycerides to tissues
