Diuretics Flashcards
1
Q
Carbonic Anhydrase Inhibitor action site
A
proximal convoluted tubule
2
Q
osmotic diuretics action site
A
descending loop of henle
3
Q
loop diuretics action site
A
ascending loop of henle
4
Q
thiazide action site
A
distal convoluted tuble
5
Q
potassium sparing diuretic site
A
collecting tubule
6
Q
thiazide diuretics
A
- act on DCT
- inhibit Na+ transporter (decrease reabsorption)
- reduce BP and PVR
7
Q
thiazide uses
A
- hypertension
- heart failure
8
Q
thiazide drugs
A
- chlorthalidone / thalitone
- hydrochlorothyazide / microzide
9
Q
loop diuretics
A
- inhibit ion transport in ascending loop
- less H2O reabsorbed
- stronges diuretic
10
Q
loop diuretic uses
A
- edema
- hyperkalemia/hypercalcemia
11
Q
loop diuretic drugs
A
- bumetanide / bumex
- ethacrynic acid / edecrin
- furosemide / lasix
- torsemide / demadex
12
Q
potassium sparing diuretics
A
- act on collecting tubule
- aldosterone antagonists
- triamterine and amiloride
13
Q
carbonic anhydrase inhibitor
A
- acetazolamide
- inhibit H2O and CO2 -> H+ and HCO3-
- mild diuresis from inhibited H+/Na+ exchange
14
Q
Osmotic Diuretics
A
- mannitol
- prevent water reabsorbtion in descending loop
- cause aquaresis - no Na+ excretion
- maintains urine flow to prevent renal failure
