Anticoagulants Flashcards
1
Q
3 pathways platelet inhibitors can block
A
COX1, GPIIb/IIIa, ADP
2
Q
Aspirin
A
- Irreversible platelet inhibitor (COX1) (5-10 days)
- NSAID/Antichiritic
3
Q
Clopidogrel/prasugrel
A
- Irreversible platelet inhibitor (P2Y) (5-10 days)
- inhibit binding of ADP
- prevention of events of thrombotic events after MI
- prevents thrombotic events with stent placement
4
Q
Tirofiban/Eptofibatide
A
- Antiplatelet drugs
- GP IIb/IIIa inhibitor
5
Q
Anticoagulant coagulation factors
A
- Protein C
- Protein S
- ATIII
- Tissue factor pathway inhibitor
6
Q
Heparin
A
- binds to ATIII - potentiates 1000 fold
- > inhibits circulating thrombin and activated coagulation factors
7
Q
low molecular weight heparin
A
- longer half-life
- more predictable response
- higher bioavailability
- can be used by outpatients
8
Q
Dabigitran
A
- direct thrombin inhibitor
- stroke prevention and atrial fibrillation
- oral anticoagulant
9
Q
Argatroban
A
- parenteral direct thrombin inhibitor
- monitor via PTT
- 50 min half life
10
Q
Bivalruden
A
- parenteral direct thrombin inhibitor
- monitor via PTT
- 25 min half life
11
Q
Warfarin/coumadin
A
- inhibits vitamin K synthesis (necessary for cofactor synthesis in liver)
- goal of 2-3x INR
- no effects for 8-12 hours
- reversed by administering vitamin K
12
Q
Streptokinase/urokinase
A
- thrombolytic agents
- convert plasminogen to plasmin -> dissolve clot
- treat DVT, PE, MI, stroke
13
Q
Alteplase (tissue plasminogen activator)
A
- activates plasminogen to break down clots
- given with stroke and MI
14
Q
Aminocaproic acid
A
- inhibits plasminogen activators (streptokinase/urokinase
- treats excessive postoperative bleeding
15
Q
Tranexamic Acid
A
- inhibits plasminogen activators (streptokinase/urokinase
- treats excessive postoperative bleeding
- 10x more potent than aminocaproic
