Host defense Flashcards
Innate response
Functions in normal host without prior expose to invading microbes
Adaptive response
Consist of antibody response (humoral) and lymphocite-mediated response tailored to particular microbial infection and characterized by MEMORY
T or F
Innate response occurs in minutes to hours and is for specific molecules associated with pathogens
TRUE
What type of immunity doesnt have memory
Innate immunity
Innate immunity has many antimicrobial peptides and proteins… what are they?
Phagocytes (monocytes, macrophages, neutrophils)
NK
Dendtritic cells
T of F
Adaptive immunity takes longer, is higly specific but has no memory
FALSE
Has memory
Adaptive immunity cells and antibodies
T cells
B cells
Antigen-presenting cells
Type 1 interfeurons
Alpha are leukocytes
Beta are fibroblast
What are. The producer cells (4)
Leukocytes
Fibroblast
Macrophages
Epithelial cells
What are the inducing agents of interferurons
Viruses and double stranded RNA
Major activity of interfeurons
Antiviral action
Defective IFN response (2)
Reduce ability to contain infection
Increased illness and death
Cells involved in defense against microbes
Phagocytic cells
Lymphocytes
Eisonophils
Phagocytic cells
Polumorphonuclear neutrophils Mononuclear phagocytes (monocytes in blood, macrophage in tissue)
Lymphocytes
B cells (antibodies) T cells (cellular immune response, helps b cells in Ab production NK cells
What lymphocyte cells are the antibodies
B cells
What is phagocytosis
Engulfment and digestion of infectious agents or foreign bodies by phagocytiic cells
Multiphasic act (5)
Bacterium becomes attached to membrane envaginations called pseudopodia
Then bacterium is ingested forming phagosome
The phagosome fused with lysosome
Lysosomal enzymes digest captured material
Digestion products released from cells
Pathogen recognition in innate response
Pattern recognition receptors (PRRs)
Missing/altered self receptors (NK cells)
Pathogen recognition for adaptive response
Antigen presentation (MHC)
Antibodies
T cell. Receptors
Neutrophils function
1ry function to phagocytize and kill EC bacterial and yeast pathogens in acute inflammation
T or F
Neutrophils live longer than a day and contain lysosomes
False
1 day
Granules not lysosomes
Acute inflammatory response are by
Neutrophils
What is your defense againts helminths
EISONOPHILS
Adaptive immunity
Adaptive, specific immune response are induced by exposure to an antigen, specific for inducing antigen, and immunologic memory is generated
