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Principles of Infectious Diseases > Host defense > Flashcards

Host defense Flashcards

1
Q

Innate response

A

Functions in normal host without prior expose to invading microbes

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2
Q

Adaptive response

A

Consist of antibody response (humoral) and lymphocite-mediated response tailored to particular microbial infection and characterized by MEMORY

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3
Q

T or F

Innate response occurs in minutes to hours and is for specific molecules associated with pathogens

A

TRUE

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4
Q

What type of immunity doesnt have memory

A

Innate immunity

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5
Q

Innate immunity has many antimicrobial peptides and proteins… what are they?

A

Phagocytes (monocytes, macrophages, neutrophils)
NK
Dendtritic cells

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6
Q

T of F

Adaptive immunity takes longer, is higly specific but has no memory

A

FALSE

Has memory

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7
Q

Adaptive immunity cells and antibodies

A

T cells
B cells
Antigen-presenting cells

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8
Q

Type 1 interfeurons

A

Alpha are leukocytes

Beta are fibroblast

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9
Q

What are. The producer cells (4)

A

Leukocytes
Fibroblast
Macrophages
Epithelial cells

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10
Q

What are the inducing agents of interferurons

A

Viruses and double stranded RNA

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11
Q

Major activity of interfeurons

A

Antiviral action

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12
Q

Defective IFN response (2)

A

Reduce ability to contain infection

Increased illness and death

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13
Q

Cells involved in defense against microbes

A

Phagocytic cells
Lymphocytes
Eisonophils

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14
Q

Phagocytic cells

A 
Polumorphonuclear neutrophils
Mononuclear phagocytes (monocytes in blood, macrophage in tissue)
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15
Q

Lymphocytes

A 
B cells (antibodies)
T cells (cellular immune response, helps b cells in Ab production
NK cells
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16
Q

What lymphocyte cells are the antibodies

A

B cells

17
Q

What is phagocytosis

A

Engulfment and digestion of infectious agents or foreign bodies by phagocytiic cells

18
Q

Multiphasic act (5)

A

Bacterium becomes attached to membrane envaginations called pseudopodia
Then bacterium is ingested forming phagosome
The phagosome fused with lysosome
Lysosomal enzymes digest captured material
Digestion products released from cells

19
Q

Pathogen recognition in innate response

A

Pattern recognition receptors (PRRs)

Missing/altered self receptors (NK cells)

20
Q

Pathogen recognition for adaptive response

A

Antigen presentation (MHC)
Antibodies
T cell. Receptors

21
Q

Neutrophils function

A

1ry function to phagocytize and kill EC bacterial and yeast pathogens in acute inflammation

22
Q

T or F

Neutrophils live longer than a day and contain lysosomes

A

False
1 day
Granules not lysosomes

23
Q

Acute inflammatory response are by

A

Neutrophils

24
Q

What is your defense againts helminths

A

EISONOPHILS

25
Q

Adaptive immunity

A

Adaptive, specific immune response are induced by exposure to an antigen, specific for inducing antigen, and immunologic memory is generated

Principles of Infectious Diseases (12 decks)

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