Hormones and Hormone Antagonists Flashcards
Prototype Drug: Vincristine (Oncovin)
•Therapeutic classification –Antineoplastic •Pharmacologic classification –Vinca alkaloid, mitotic inhibitor, natural product •Pregnancy category D
•Contraindications –Obstructive jaundice –Men and women of childbearing age –Active infection –Adynamic ileus –Radiation of the liver –Infants –Pregnancy –Lactation
•Adverse effects
–GI-related effects: nausea, vomiting, anorexia, stomatitis, severe constipation, abdominal pain
–Hepatotoxicity, rash, paralytic ileus, alopecia
–Myelosuppression may occur
–Extravasation can cause intense pain, inflammation, and tissue necrosis
•Patient/family teaching
–Immediately report stomach, bone, or joint pain and swelling of lower legs and ankles to health care provider
–Start a preventive regimen against constipation
–Reversible hair loss is most common adverse reaction and may persist for duration of therapy
Prototype Drug: Tamoxifen (Nolvadex, Soltamox)
•Therapeutic classification –Antineoplastic •Pharmacologic classification –Hormonal agent, estrogen receptor blocker •Pregnancy category D
•Contraindications –Anticoagulant therapy –Preexisting endometrial hyperplasia –History of thromboembolic disease –Pregnancy –Lactation
•Adverse effects –Nausea –Vomiting –Hot flashes –Vaginal discharge –Irregular menses –Vaginal bleeding -Fluid retention –Headaches –Light-headedness –Rash
•Patient/family teaching
–Take drug exactly as prescribed
–Immediately report occurrence of marked weakness, sleepiness, mental confusion, edema, dyspnea, and blurred vision to health care provider
–Report drug-induced menstrual irregularities to health care provider
–Avoid prolonged sun exposure
–Avoid OTC drugs, particularly pain medicines, unless specifically approved by health care provider
–Report onset of tenderness or redness in an extremity
