Antimetabolites Flashcards
1
Q
Prototype Drug: Methotrexate (MTX, Rheumatrex, Trexall)
A
•Therapeutic classification –Antineoplastic •Pharmacologic classification –Antimetabolite, folic acid analog, immunosuppressant, disease-modifying antirheumatic drug (DMARD) •Pregnancy category X
•Contraindications –Thrombocytopenia –Anemia –Leukopenia –Concurrent administration of hepatotoxic drugs and hematopoietic suppressants –Alcoholism –Lactation
•Adverse effects
–Nausea
–Vomiting
•Patient/family teaching –Avoid alcohol –Practice fastidious mouth care –Avoid exposure to sunlight and ultraviolet light –Do not self-medicate with vitamins -Avoid echinacea –Limit intake of caffeine –Use contraceptive measures during and for at least 8 weeks following therapy
