Antitumor Antibiotics Flashcards
1
Q
Prototype Drugs: Doxorubicin (Adriamycin)
A
•Therapeutic classification –Antineoplastic •Pharmacologic classification –Antitumor antibiotic, anthracycline •Pregnancy category D
•Contraindications –Pregnancy –Lactation –Myelosuppression –Thrombocytopenia -Preexisting cardiac disease –Obstructive jaundice –Previous treatment with complete cumulative doses of doxorubicin or daunorubicin
•Adverse effects –Turns urine and tears a red color –Temporary decreased fertility –Secondary malignancies –Nausea –Vomiting –Rash –Mucositis –Excessive lacrimation
•Patient/family teaching
–Expect complete loss of hair (reversible), which may also involve eyelashes and eyebrows, beard and mustache, and pubic and axillary hair
–Expect urine to become red for 1 to 2 days after administration
