Hormoner: Hypothalamus og hypofysen Flashcards

1
Q

Adenohypofysen

A

Forlappen

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2
Q

Neurohypofysen

A

Baglappen

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3
Q

En generel hormonel kaskade

A

Stimulus –> Hypothalamus: higher hormone 1 secretion –> Higher plasma hormone 1 –> Anterior pituitary: higher hormone 2 secretion –> higher plasma hormone 2 –> Third endocrine gland: higher hormone 3 secretion –> higher plasma hormone 3 –> target cells of hormone 3: respond to hormone 3

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4
Q

Hypofysiotrofe hormoner og deres effekt på adenohypofysen

A

GnRH –> stimulerer sekretion af LH og FSH

GHRH –> stimulerer sekretion af growth hormone

SST –> inhibits sekretion af growth hormone

TRH –> stimulerer sekretion af af TSH

DA –> inhibits sekretion af prolactin

CRH –> stimulerer sekretion af ACTH

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5
Q

FSh og LH nedstrømseffekter

A

Gonads:
-germ cell development
- secrete hormones

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6
Q

Growth hormone nedstrømseffekter

A

Liver and other cells:
- Secrete IGF-1

Many organs and tissue:
- Protein synthesis, carbohydrate and lipid metabolism

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7
Q

TSH nedstrømseffekter

A

Thyroid:
- secretes thyroxine, triiodothyronine

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8
Q

Prolactin nedstrømseffekter

A

Breasts:
- breast development and milk produktion

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9
Q

ACTH nedstrømseffekter

A

Adrenal cortex:
- secretes cortisol

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10
Q

Generel mekanisme for feedback regulering

A

Short-loop feedback: Negativ. fra plasma hormon 2 –> Hormone 1 secretion

Long loop feedback: Negativ. fra plasma hormon 3 til hormone 2 og 1 secretion

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11
Q

Vigtigt at huske

A

1) forbindelserne mellem hypothalamus og hypofysen
2) Forskellen mellem neuro- og adenohypofysen med hensyn til hormonproduktion
3) De hypofysiotrofe hormoner (især GHRH, SST, TRH og CRH)
4) Adenohypofysens hormoner (isør GH, TSH og ACTH) og deres nedstrømseffekter
5) Principperne i feedback-regulering

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