Hormone Replacement Therapy

Question 1

What type of HRT should a woman that is still having periods be on?

Answer 1

Cyclical HRT with cyclical progesterone

Question 2

What type of HRT should women without a uterus be on?

Answer 2

Oestrogen-only HRT

Question 3

What type of HRT should women who have not had periods for more than 12 months be on?

Answer 3

Continuous combined HRT

Question 4

Why is progesterone given to women with a uterus?

Answer 4

To protect the endometrium from endometrial hyperplasia and endometrial cancer, caused by the oestrogen

Question 5

What is clonidine?

Answer 5

Clonidine is a alpha-2 adrenergic receptor agonist that can be useful for vasomotor symptoms and hot flushes

Question 6

What are the indications for HRT?

Answer 6

Replacing hormones in premature ovarian insufficiency
Reducing vasomotor symptoms
Improving symptoms of reduced libido, poor sleep and low mood
Reducing osteoporosis risk

Question 7

What are the risks of HRT?

Answer 7

Increased risk of breast cancer
Increased risk of endometrial cancer
Increased risk of venous thromboembolism
Increased risk of stroke

Question 8

What are the contraindications to HRT?

Answer 8

Undiagnosed abnormal bleeding
Endometrial hyperplasia
Breast cancer
Uncontrolled hypertension
Venous thromboembolism
Liver disease
Angina or previous MI
Pregnancy