HLAs

Question 0

HLA-B27

Def’n, Seen In (4: “CRAP”)?

Answer 0

Gene that codes for HLA MHC I.

SEEN IN Seronegative Spondyloarthropathies: “CRAP”

• Crohn’s
• Reactive Arthritis
• Ankylosing Spondylitis
• Psoriatic Arthritis

** Conditions that can push an HLA-B27 person into
Ankylosing Spondylitis: Psoriasis, Chlamydia, Ulcerative Collitis **

Question 1

HLA-A3

Seen In?

Answer 1

SEEN IN:

- 1ry Hemochromatosis

Question 2

HLA-C

Answer 2

Psoriasis

Question 3

HLA-DQ2 or -DQ8

Seen In?

Answer 3

SEEN IN:

- Celiac’s Dz

Question 4

HLA-DR2

Seen In (4)?

Answer 4

SEEN IN:

• Goodpasture Sx
• Hay Fever
• SLE
• MS

Question 5

HLA-DR3

Seen In (3)?

Answer 5

SEEN IN:

• Diabetes Mellitus I
• Graves Dz
• SLE

Question 5

HLA-DR4

Seen In (2)?

Answer 5

SEEN IN:

• Diabetes Mellitus I
• RA

Question 7

HLA-DR5

Seen In (2)?

Answer 7

SEEN IN:

• Hashimoto’s Thyroiditis
• Pernicious Anemia -> Vit B12 def