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Findings > Antibodies > Flashcards

Antibodies Flashcards

1
Q

Heterophile Antibodies

A

EBV (Infectious Mono)

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2
Q

Anti-Alveolar Basement Membrane Antibodies

A

Goodpasture Sx

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3
Q

Anti-Centromere Antibodies

A

Limited Scleroderma (CREST Sx)

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4
Q

Anti-Cyclic Citrullinated Peptide Antibody

A

RA

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5
Q

Anti-Cardiolipin Antibodies (ACAs)

Def’n, Seen In (2)?

A

Type of APLA (anti-phospholipid antibody).
↑risk of blood clots and/or pregnancy loss.

SEEN IN:

  • Antiphospholipid Sx
  • SLE
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6
Q

Anti-DNA Topoisomerase I (Anti-Scl 70)

Seen In?

A

SEEN IN:

- Diffuse Scleroderma

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7
Q

Anti-Desmoglein Antibodies (IgG antibodies)

Seen In, Appearance on Immunofluorescence (IF)?

A

SEEN IN: Pemphigus Vulgaris

IF:
- Ab around epidermal cells in “netlike” / reticular pattern

(Desmoglein = component of desmosomes.
Desmosomes connect keratinocytes in stratum spinosum.)

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8
Q

Anti-DNase B Antibodies

Def’n,↑Levels In (2)?

A

Antibodies to DNase B (a substance produced by Group A Strep).

↑IN:

  • Acute Post-Strep Glomerulonephritis
  • Rheumatic Fever
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9
Q

Anti-Glomerular Basement Membrane Antibodies

A

Goodpasture Sx: necrotizing glomerulonephritis with linear IgG deposition on glomerular basement membrane.

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10
Q

Anti-dsDNA Autoantibodies

Seen In?

A

SEEN IN:

- SLE ( -> Renal Disease )

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11
Q

Anti-Glutamate Decarboxylase Autoantibodies

Seen In?

A

SEEN IN:

- Type I DM

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12
Q

Anti-Gliadin / Anti-Transglutaminase / Anti-Endomysial IgA Autoantibodies

Seen In?

A

SEEN IN:

- Celiac Disease

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13
Q

Anti-Histone Antibodies

Seen In?

A

SEEN IN:

- Drug-Induced SLE

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14
Q

Anti-Hemidesmosome Antibodies (IgG antibodies)

Seen In, Appearance on IF?

A

SEEN IN:
- Bullous Pemphigoid

(Hemidesmosomes in epidermal basement memb = below epidermis)

IF:
- Linear pattern at epidermal-dermal junction

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15
Q

Anti-Jo1 Autoantibodies

Seen In?

A

SEEN IN:

- Dermato- + Polymyositis

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16
Q

Antimicrosomal Antithyroglobulin Autoantibodies

Def’n, Seen In?

A

Sign of Thyroid damage.

SEEN IN:
- Hashimoto’s Thyroiditis

17
Q

Anti-Mitochondrial Antibodies (AMA)

A

Primary Biliary Cirrhosis

18
Q

Anti-Nuclear Autoantibodies (ANA): Anti-SSA / SSB
(ie Anti-Ro / -La)

Seen In (3)?

A

SEEN IN:

  • Sjorgen’s Sx
  • SLE
  • Libman-Sacks Endocarditis
19
Q

Anti-Neutrophil Cytoplasmic Antibodies (ANCA)

Def’n, Seen In?

A

Autoantibodies (primarily IgG) against antigens in the cytoplasm of Neutrophils.

SEEN IN:
- Vasculites

20
Q

C-ANCA (Cytoplasmic ANCA / PR3-ANCA)

Def’n, Seen In (2)?

A

ANCA with CYTOPLASMIC + diffusely GRANULAR staining pattern.

SEEN IN:

  • RPGN
  • Wegener Granulomatosis (Granulomatosis w polyangitis)
21
Q

P-ANCA (Perinuclear ANCA / MPO-ANCA)

Def’n, Seen In (4)?

A

ANCA with PERINUCLEAR staining pattern.

SEEN IN:

  • RPGN
  • Churg-Strauss Sx
  • Microscopic Polyangitis
  • Polyarteritis Nodosa
22
Q

Anti-Platelet Antibodies

IgG against platelet antigens Gp 2b/3a

A

Idiopathic Thrombocytopenic Purpura

22
Q

Anti-Mi2 Autoantibodies

Seen In?

A

SEEN IN:

- Dermato- + Polymyositis

23
Q

Anti-Smith Autoantibodies

Def’n, Seen In?

A

Antibodies against Smith antigen: part of snRNAs + snRNPs

SEEN IN:
- SLE

24
Q

Anti-Smooth Muscle Autoantibodies

Seen In?

A

SEEN IN:

- Autoimmune Hepatitis

25
Q

Anti-SRP Autoantibodies

Seen In?

A

SEEN IN:

- Dermato- + Polymyositis

26
Q

Antithyroglobulin Autoantibodies

Seen In?

A

SEEN IN:

- Hashimoto Thyroiditis

27
Q

Anti-Topoisomerase Antibodies (ie Anti-Scl70)

A

Diffuse Systemic Scleroderma

28
Q

Anti-U1 RNP Autoantibodies

Seen In?

A

SEEN IN:

- Mixed Connective Tis Dz

29
Q

Rheumatoid Factor

Def’n, Mech (4 steps), Seen In (2)?

A

Anti-IgG antibody (IgM against IgG).

MECH:
Attacks IgG in synovial tis -> Infl ->
Destruction of articular cartilage ->
Joint Fibrosis + potential Ankylosis (if joint isn’t moved).

SEEN IN:

  • Rheumatoid Arthritis
  • Rheumatic Fever
30
Q

Autoantibodies against Ca Channels

A

Lambert-Eaton Myasthenic Sx

31
Q

Autoantibodies against Insulin

Seen In?

A

SEEN IN:

  • Type 1 DM (often)
    • May be seen years before clinical dz presents *
32
Q

Autoantibodies to Ribonucleoprotein Antigens:
SS-A (Ro), SS-B (La)

Seen In?

A

SEEN IN:

- Sjogren’s Sx

33
Q

Autoantibodies against Ach Receptor

Seen In?

A

SEEN IN:

- Myasthenia Gravis

34
Q

Autoantibodies against TSH receptor

Seen In?

A

SEEN IN: Graves Dz

35
Q

Monoclonal Antibody Spike

Seen In (4)?

A

SEEN IN:

  • Monoclonal Gammopathy of Undetermined Significance
  • Multiple Myeloma (IgG or IgA)
  • Primary Amyloidosis
  • Waldenstrom Macroglobulinemia (IgM)

Findings (19 decks)

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