HIV

Question 1

Risk factors for HIV?

Answer 1

Injected drug use, sexual activity

Question 2

Where is HIV most common

Answer 2

India, Africa, Russia

Question 3

Why is multi-drug therapy so important

Answer 3

Because resistance can easily develop as the reverse transcriptase enzyme is capable of mutating easily

Question 4

HIV stands for?

Answer 4

Human immunodeficiency virus

Question 5

2 tests used to diagnose HIV are?

Answer 5

• antibody / antigen test - like a RAT - gives you a yes or no (qualitative)
• viral RNA PCR - quantitative - can monitor the viral load

Question 6

Normal triple class therapy for HIV?

Answer 6

2 x NRTI and 1 other (typically an integrase inhibitor)

Question 7

Name an NRTI

Answer 7

Azidothymidine

Question 8

Name an integrate inhibitor

Answer 8

Raltegravir

Question 9

Patients on HIV therapy need to be monitoring for what complications?

Answer 9

Cardiovascular. Drugs can cause dyslipidaemia and impaired glucose tolerance
Also need to monitor drug interactions

Question 10

How can mother to child transmission of HIV be reduced?

Answer 10

Encourage C section delivery, avoid breastfeeding, treat mother, peri-partum prophylaxis

Question 11

Compare PrEP and PEP

Answer 11

Pre-exposure vs post exposure prophylaxis
Both can be done for HIV