GIT Flashcards

1
Q

What are the most concerning complications of gastroenteritis?

A

Dehydration and malnutrition

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2
Q

Complication of gastroenteritis in pregnant women?

A

Spontaneous abortion. This is why they are cautioned against high risk foods

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3
Q

Most common viral cause of gastroenteritis?

A

Norovirus (no vaccine) or rotavirus (vaccine available)

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4
Q

Name 3 bacteria that can cause bacterial gastroenteritis

A

Salmonella, campylobacter, e. Coli

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5
Q

Which is the most severe variation of E. coli? ETEC or STEC

A

STEC

Can lead to HUS - haemolytic uraemia syndrome which can cause kidney failure

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6
Q

Which has the fastest onset - ETEC or STEC e.coli?

A

ETEC - within 1-3 days of exposure

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7
Q

Difference between e.coli infection of campylobacter infection?

A

Campylobacter only requires a very small number of organisms to cause an infection, whereas e.coli requires a lot

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8
Q

Name focus for gastroenteritis treatment?

A

Rehydration and supportive Tx

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9
Q

Why are antibiotics not used in STEC?

A

Because they increase the release of the toxins from STEC that cause HUS - the complication that can lead to kidney failure

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10
Q

Why are antibiotics not really used for gastroenteritis?

A

Most cases are self limiting

+ the ADRs of ABs are similar to the Sx of GE

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11
Q

Which vaccine is recommended to travelers

A

Typhoid fever vaccine - associated with salmonella

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12
Q

Examples of supportive treatment?

A

Anti-motility (rarely recommended), anti-emetics, anti-spasmodic (buscopan)

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13
Q

When might prophylaxis be considered for travellers?

A

Only if at high risk - e.g. immunocompromised

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14
Q

What is helminths

A

Infection with worms (e.g. tapeworm, roundworm)

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15
Q

Where is helminths most prevalent

A

In developing countries - transmitted through soil where sanitation is poor

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16
Q

How does infection with H. Pylori affect the GIT?

A

It increases production of gastric acid, leading to development of ulcers and gastritis and even stomach cancers

17
Q

Triple therapy for H. Pylori infection?

A

PPI bd, clarithromycin bd and amoxicillin bd

Can replace either of the ABs with metronidazole if needed

18
Q

Which infection is most likely to require a faecal microbiota transplant? C. Diff or H. Pylori

A

C. Diff

19
Q

Risk factors for c diff infection?

A

Long hospital stays, broad spectrum AB treatment, PPI use

20
Q

Why should you avoid antimotility drugs in c. Diff infections?

A

Can cause toxic megacolon

21
Q

Compare Tx for c. Diff for mild vs severe

A

Mild / moderate - metronidazole

Severe - vancomycin