History of Microbiology Flashcards

1
Q

Microbiology in a Dental Setting

  • ________ life-forms are typically _______ cell organisms or composed of _______ cells
  • Microorganisms are the most ______ life-forms on the planet representing the largest ________
  • Some microorganisms can be ________ or ________ to humans, this can be determined by _______, comparison of _______, and the application of a stringent set of _______
  • Microorganisms make important contributions to _____ _______ diseases
A
  • Miscroscopic; single; single
  • Abundant; biomass
  • helpful; harmful; isolation; properties; guidelines
  • oral infectious
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2
Q
  • _________: The science that deals with microscopic living organisms and their effects on other forms of life, including the study of _____, which are NOT independent ________ organisms
  • _______, _________ & _________ biology are the tools used to study microorganisms
A
  • Microbiology; viruses; living

- Biochemistry; genetics & molecular

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3
Q

___________ _________ van ___________ (1632-1723)

  • Dutch merchant who made the first __________
  • The first person to study _________, and publish the first drawings of __________ organisms by viewing samples from his mouth
  • __________: What he called microorganisms
  • Responsible for the first observations of _______ ever recorded
A
  • Antonie Philips van Leeuwenhoek
  • Microscope
  • Microorganisms; microscopic
  • Animalcules
  • Bacteria
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4
Q

Robert _______ Microscope

-Responsible for discovering the _____

A
  • Hooke

- Cell

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5
Q

Francesco Redi (1626-1697)

  • Considered to be the founder of _______ biology, and the father of modern ________-
  • First person to challenge the idea of _______ _______, which believed that life arose simply from ______ matter
A
  • Experimental; parasitology

- Spontaneous generation; organic

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6
Q

Redi Experiment

  • Used ______ _____ to show that the reason _____ appeared was due to flies
  • First step to prove that ______ _______ of life was false
A
  • Rotted meat; maggots

- Spontaneous generation

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7
Q

______ ______ (1795-1840)

  • AKA Paul ____
  • Created a painting called ______ _______ that represented the public’s perception in the early 1800s of _______ disease. Inaccurately represented _____ as ______
A
  • William Heath
  • Paul Pry
  • Monster Soup; infectious; microbes; monsters
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8
Q

Theodore ______ (1810-1882)

  • Also challenged and disproved the concept of _______ ________
  • Came up with the ___ _____
  • Discovered that ____ carry out chemical reactions, aka ______
A
  • Schwann
  • Spontaneous generation
  • Cell theory
  • cells; metabolism
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9
Q

Cell Theory

  1. All ________ organisms are composed of one or more _____
  2. The _____ is the basic unit of _________ and _______ in organisms
  3. ______ arise from pre-existing ______
    - _____ _____ Schleidon contributed to the Cell Theory too
A
  1. Living; cells
  2. Cell; structure; organization
  3. Cells; cells
    - Matthias Jakob Schleidon
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10
Q

Louis _______ (1822-1895)

  • Originally was a ________
  • Crooked-neck ______ experiment helped to disprove ______ ______ by showing that microorganisms were in the ____ and exposure led to contamination
  • Only the flasks with the _______ necks became contaminated after being exposed to the ___________
  • _________: The process by which food is exposed to a temperature of _______F for _____ minutes and then cooled, killing only the microbes that cause _____ or ______. Did not negatively affect _______ of the products
A
  • Pasteur
  • Chemist
  • Flask; spontaneous generation; air
  • Broken; atmosphere
  • Pasteurization; 145F; 30; spoilage; disease; quality
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11
Q
Pasteurized Foods
-\_\_\_\_\_\_\_
-\_\_\_\_\_\_\_
Alcoholic Beverages:
-\_\_\_\_\_\_\_ 
-\_\_\_\_\_\_\_
A

-Milk
-Cheese
Alcoholic Beverages:
-Beer
-Wine

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12
Q

_______ Tyndall (1820-1893)

  • Found that lowering the ______ _______ lowered the _______ point of a liquid, causing it to ______ at a lower temperature
  • Found that ______ pure air lacked __________
  • Responsible for the process of __________
  • ___________: Process by which food is sterilized by _______ for several minutes at atmospheric pressure 3-4 _________ times separated by _____ hours of incubation at a temperature favorable for ________ growth. Effective process for ______ and is used in ______ foods
  • ________: Complete elimination of life
A
  • John
  • Vapor pressure; boiling; boil
  • Optically; contamination
  • Autoclaving
  • Tyndalization; steaming; successive; 12-18; bacterial; sterilization; canning
  • Sterilization
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13
Q
  • _______ Fauchard (1678-1761)
  • Known for writing the first complete scientific description of _________: Le Chirurgien Dentiste
  • Able to preserve ____________ & _________ teeth by treating the ______, the first association of ________ and human infections
  • Considered the _________ of _________ Dentistry
A
  • Pierre
  • dentistry
  • Decaying & Defective; pulp; microorganisms
  • Father of Modern Dentistry
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14
Q

Ignaz _______ (1818-1865)

  • Worked with _______ women
  • Found that _______ ______ with _______ lime solutions saved lives by reducing the incidence of _______ ______: Uterine infection following childbirth
  • Promoted the idea of _______
A
  • Semmelweis
  • pregnant
  • Washing hands; chlorinated; Puerperal Fever
  • Handwashing
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15
Q

_________ Lister (1867-1912)

  • _______ ______: The belief that infections/infectious diseases are caused by the activity of______ in the human body
  • _________: The process of eliminating MOST of the contaminating microorganisms
  • Used phenol/_____ _____ as a disinfectant
  • _________ was named after Lister in 1895 for dentists to use
A
  • Joseph
  • Germ Theory; microbes
  • Disinfection; Carbolic Acid
  • Listerine
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16
Q

Civil War

  • Many deaths occurred due to _____
  • ______: Bad, smelly air or poisonous vapor from decomposing organic matter believed to be responsible for _______ and ultimately death
A
  • Infection

- Miasma; infections

17
Q

-Assassination of President ______ A. ______ in 1881 was due to the result of massive _______ more so than injuries

A

-James A. Garfield; infection

18
Q
  • ____ ______ has 2 very famous paintings:
    1. _______ Clinic (1875)
    2. The _____ Clinic (1889)
  • Depicts _____, Penn’s leading surgeon at the time
  • Both images depict surgeries performed with no effort to control _______, since_____ wasn’t accepted yet
A
  • Thomas Eakins
    1. Gross
    2. Agnew
  • Agnew
  • infections; disinfection
19
Q

_______ Koch (1843-1910)

  • Won the _____ Nobel Prize for Physiology or Medicine
  • ______ ______: A series of rules to prove a specific microorganism causes a specific disease
    1. The microorganism must be found in the ______ organism, but not in ______ animals
    2. The microorganism must be grown in ______ _____ from a ________ animal
    3. The cultured microorganism must produce the _____ in a ______ susceptible animal
    4. The microorganism must be re-_________ from an infected animal
  • Doesn’t work for all diseases when considering the ______ susceptibility of an individual and that some _______ are caused by more than 1 microorganism
A
  • Robert
  • 1905
  • Koch’s Postulates
    1. Diseases; healthy
    2. pure culture; diseased
    3. disease; healthy
    4. isolated
  • immune; diseases
20
Q

Important Outcomes of Koch’s Work:

  • Invention of the _____ medium, a technician’s wife suggested ______ should be used
  • Necessity of obtaining _____ ______
  • Some diseases are the result of the activities of _______ microorganisms, like with Mycobacterium _________
A
  • agar; agar
  • Pure Cultures
  • Specific; Tuberculosis
21
Q

Unique Properties of Agar

  • Becomes a ____ when cooled to room temperature
  • Was used for preserving ____ at the time
  • Derived from _____
  • Provided the means to _____ and _____ bacterial colonies
A
  • gel
  • jellies
  • algae
  • spread and isolate
22
Q

Wiloughyby Dayton (W.D.) ______ (1853-1907)
-Established the ________-______ theory of dental caries (1889), re-orienting the dental profession from one of ____ to the idea of ______ of disease
-Associated _____ with dental _____
-Published a study reporting the association of bacteria with apical ________ following samples from root _____
-Member of the first graduating class of _____ _______ _____
Observed 3 basic morphologies:
-_____
-______
-______/_______

A
  • Miller
  • Bacterio-chemical; treatment; prevention
  • microbes; caries
  • periodontitis; canals
  • Penn Dental Medicine
  • Cocci
  • Bacilli
  • Spirilla/Spirochetes
23
Q

Importance of Microbiology in Dentistry

  • Oral Infectious Diseases:
  • Dental _______
  • _______ disease
  • _____-_____ fistula
  • _______/Oral Thrush: Yeast infection of the oral cavity
  • Oral ______
  • Can be caused by _____, ______, or _____
  • _____ _____: Shows plaque accumulation
  • _______ _____: Bacteria will attach to valves in the heart and this originates from microbes in the oral cavity
A
  • Caries
  • Periodontal
  • Extra-oral
  • Candidiasis
  • Herpes
  • bacteria; viruses; fungi
  • Disclosing solution
  • Infective Endocarditis
24
Q
  • ____ _____: Caused by pathogenic microorganisms (______, ______, parasites or _____) that can be spread, directly or indirectly, from one person to another
  • ____ _____: Infectious diseases of animals caused my microorganisms that can cause disease when transmitted to humans
  • _______ often spread through herds of cows and would be passed to humans through milk, why _________ is so important. Used the ________ test to screen the dairy cows
A
  • Infectious Disease; bacteria; viruses; fungi
  • Zoonotic Disease
  • Tuberculosis; pasteurization; Tuberculin
25
Q

Conditions Related to Microorganisms in the Human Oral Cavity

  • ______
  • ______: Bad breath
  • _____
  • _____ _____ ______: Milk that accumulates in the babies oral cavity as they slept with the bottle in their mouth and caries would form due to the carbohydrates present in the milk
  • _______ failure
  • ____ ______: Microbes, especially yeast, flourish underneath the dentures of the elderly
  • ______ _____: Consequence of HIV infections
A
  • Gingivitis
  • Halitosis
  • Abscesses
  • Nursing Bottle Syndrome
  • Implant
  • Denture Stomatitis
  • Kaposi’s Sarcoma
26
Q

Cause and Effect Relationship Between Bacteria and Oral Disease

  • _______ _____: Animals with significantly reduced flora or the flora is predominantly a single microorganism. Can breed them to be ______ free and often used Syrian _______
  • Paul H. Keyes performed a study with mono-infected Syrian ______ with _______ - resistant Streptococcus ______, where they ultimately developed dental _______
  • Needed to use a _______ - resistant strain of Streptococcus to test ______ ______
A
  • Gnotobiotic Animals; microbe; hamsters
  • hamsters; streptomycin; mutans; caries
  • streptomycin; Koch’s Postulates