Histology pt 2 Flashcards
Connective tissue
Consists of cells and extracellular matrix
Extracellular matrix
3-dimension network consisting of extracellular molecules and minerals such as proteins, glycoproteins, proteoglycans, minerals and hydroxyapatite providing structural and biochemical support to surrounding cells and tissue.
Non fibrous components
Ground substance
Glycosaminoglycans
Glycoproteins and proteoglycans
Ground substance
Amorphous gel-like substance in extracellular space. Composed of water and large organic molecules. Involved in movement of tissues and metabolism. Provides lubrication for fibrous component of ECM
Glycosaminoglycans
polysaccharides that trap water, giving the ground substance a gel-like texture
Glycoproteins and proteoglycans
modified proteins that have oligosaccharide or polysaccharides attachments. Give ground substance structure
Areolar tissue structure
loose, fluid-like
Allows movement of cells - ^GS
Tendon structure
Dense
Providing strength
Decreased GS
Collagen fibres
long and unbranched, flexible and provide strength to tissue
Reticular fibres - collagen and function
Consist of collagen but are thinner and branched, forming a strong but flexible structure
Found in organs where they provide structure to the organ but allow movement of cells
Elastic fibers
Made up of elastin and are branched and allow tissue to stretch up to 200% original shape
Loose connective tissue - Areolar
-Thin collagen fibres
- Reticular fibres
- Elastin fibres
Holds organs in place and provides cushioning. Attaches epithelial tissue to underlying tissue and allows cell movement e.g phagocytic cells which provide defense against pathogens
Loose connective tissue - Adipose tissue
-Reticular tissue
- Collagen III
-High GS
Provides cushioning, insulation; stores energy.
Obesity in cells
increased GS which leads to increased PG. PG bind to inflammatory/immune cells and increase inflammation which leads to a metabolic disease
Loose connective tissue - Reticular
Collagen III
Increased GS
Fibres from a supporting skeleton for organs and allows movement of cells and fluids