HISTOLOGIC DEF Flashcards
Hypercellular Stroma compressing associated ephithelium (Mamary tissue)
Fibroadenoma
a mass that increases in size in response to estrogen. As such, enlargement of the mass is often seen during pregnancy, prior to menstruation, or following initiation of combination oral contraceptive pills.
Young Women
Fibroadenoma (bening)
high-risk features of cancer
necrosis, calcifications
connective tissue and cysts with “leaf-like” lobulations.
phyllodes tumor (bening)
Cyst lined by metaplastic apocrine cells
Fibrocystic change
- Most common in premenopausal women
- Multiple, bilateral, painful breast lumps
- “Lumpy bumpy” breast masses
- Symptoms are associated with ↑ estrogen
proliferation of Papillary cells with fibrovascular core
intraductal papilloma (bening) \+bloody or serosanguineous nipple discharge!!! Buzzword: straw-color nipple discharge
Small,glandular,duct-like cell with desmoplastic stroma
Invasive ductal carcinoma
- -firm, fibrous, “rock-hard” mass with sharp margins
- -older woman
Eczematous patches over the nipple and areolar skin
Pagett Dx
Shed epithelia within the mucous are described as whorls
ASMA
eosinophils infiltrating in the lamina propria, “charcot liden crystals” CON plugs de mucus
ASMA
Carbon-laden macrophages
- Coal workers
* ligeramente eb fumadores
*Hypertrophy of goblet cells
Bronquitis
Large alveoli associated with loss of septae
emphysema
Hypergranulosis is the increased thickness of the stratum granulosum
Lichen planous
Separation of epidermal layer (Acantholysis)
Pemphigus vulgaris
Epidermal hyperplasia
↑ spinosum layer
Acanthosis nigricans
↑ stratum corneum
Hyperkeratosis
- Callos
- Psoriasis
↑ stratum granulosum
Hypergranulosis
linchen planous
Retention of nuclei (Parakeratosis)
Stratum corneum
Actinic keratosis
Psoriasis
Edematous fluid in intercellular spaces of epidermis
Spongiosis
Eczematous dermatitis
Lung mass-> Neuroendocrine growth patterns (ie, rosettes)
Centrally or peripherally located, often grows into the lumen of the bronchi
Carcinoid Tumor
También crece en el intestino delgado
Lung mass-> Epithelial glandular tumor
Peripherally located
AdenoCA
Lung mass-> Large undifferentiated anaplastic cells, pleomorphic giant cells
Peripherally located
Large Cell Carcinoma
- gynecomastia
- Galactorrhea (Due to incresed bHcG)
Lung mass-> Sheets of round basophilic cells with scant cytoplasm (Kulchitsky cells)
Contains granules, stains positive for chromogranin, synaptophysin, neuron-specific enolase
-Centrally located (“S for central”)
SMALL CELL CA
Lung Mass-> Stratified squamous cells, keratin pearls, intercellular bridging
Metaplasia (columnar epithelium to squamous)
Gross pathology will show ***central necrosis and cavitation
Centrally located (“S for central”)
Squamous cell CA
nutmeg liver-> dilated sinusoids surrounding a pale area of normal liver tissue.
congestive hepatopathy
*** Diastolic heart failure results in venous congestion due to a backup of blood in the superior and inferior vena cava.
tumor ovarico-> tumors are composed of transitional epithelium
coffee bean nuclei
Brenner tumor
tumor ovarico-> epithelial lesions,Composed of cells resembling the fallopian tube epithelium
Ciliated columnar epithelium
Serous Cystadenoma
Solid ovarian tumor with Large,dysplastic cells with clear cytoplasm surrounding a central nucleus.
Dysgerminomas
Chocolate cyst of simple columnar epithelium with tubular glands
Endometriosis
Tall columnar cells with cellular atypia lining crowed glands (abnormal uterine bleeding)
endometrial carcinoma
display nuclear enlargement with granulation, koilocytic change, and an increased ratio of nucleus to cytoplasm.
Cervical cancer
endometrial glands and stroma penetrating the musculature of the uterus. (myometrium)
Adenomyosis
“Fried egg” cells
Germ cell ovarian carcinoma
*10-30 years of age with an adnexal mass, abdominal enlargement, abdominal pain, and abnormal vaginal bleeding
Keratin pearls
squamous cell carcinomas
