Hepatitis Viruses (20,23) Flashcards
Which hepatitis virus has the longest incubation period?
a. HAV
b. HBV
c. HCV
d. HEV
c. HCV
Which hepatitis virus has the shortest incubation period?
a. HAV
b. HBV
c. HCV
d. HEV
a. HAV
What is involved in the pathogenesis of viral hepatitis?
a. Damage is due to cytolytic actions
b. Chronic infections are more common in older individuals
c. The younger someone is exposed to hepatitis, the more severe their acute reaction
d. Most disease is mediated by the immune system
d. Most disease is mediated by the immune system
Which are acute viruses?
a. Hepatitis B and D
b. Hepatitis A and E
c. Hepatitis A and B
d. Hepatitis C and E
b. Hepatitis A and E
How can acute hepatitis infections be diagnosed?
a. A decrease in IgG titre confirms an acute infection
b. PCR can distinguish acute and chronic infection
c. Rising titre of IgM antibodies can confirm chronic infection
d. An IgM ELISA to viral proteins can demonstrate acute infection
d. An IgM ELISA to viral proteins can demonstrate acute infection
What is a feature of the hepatitis A virus?
a. It is a member of the flavivirus family
b. It has a single serotype across the world
c. It is an enveloped –ssRNA virus
d. It is sensitive to stomach acid
b. It has a single serotype across the world
What is involved in the lifecycle of hepatitis A and E?
a. After ingestion, the virus replicates in the intestinal epithelia
b. The virus is transmitted percutaneously
c. The viruses have no viremic stage
d. The virus penetrates the intestinal epithelia following ingestion
a. After ingestion, the virus replicates in the intestinal epithelia
What is not a clinical feature of hepatitis A?
a. An average incubation period of 30days
b. Symptoms including jaundice and pale faeces
c. Cirrhosis can develop as a chronic sequelae
d.
c. Cirrhosis can develop as a chronic sequelae
What is the primary method used to prevent HAV?
a. Pre exposure immune globulin
b. Supportive nutrition
c. Sanitation
d. Post exposure immune globulin
c. Sanitation
What makes up the HAV vaccine?
a. It is a whole virus vaccine inactivated by formalin
b. It does not require an adjuvant
c. It is highly effective and cheap to produce
d. It contains sub-viral particles and is cultured by yeast
a. It is a whole virus vaccine inactivated by formalin
What is a feature of the hepatitis E virus?
a. It easily passes from person to person
b. It is enveloped with helical symmetry
c. It has a 7.7kb +ssRNA genome
d. It is part of the calicivirdae family
c. It has a 7.7kb +ssRNA genome
What is correct about the transmission risk for viral hepatitis?
a. Only HBV and HCV can be transmitted sexually
b. HAV and HEV are only transmitted by intravenous drug use
c. Perinatal transmission is possible for HBV
d. HBV and HCV are transmitted in contaminated food and water
c. Perinatal transmission is possible for HBV
Which are chronic viruses?
a. Hepatitis A and B
b. Hepatitis B, C and D
c. Hepatitis A, B and D
d. Hepatitis D and E
b. Hepatitis B, C and D
What is the pre-C region?
a. It is added by HBeAg and indicates active replication of HBV
b. It encodes a HBV polymerase that reverse transcribes the preRNA into genomic DNA
c. It is removed by the core protein of HBV to signify the end of the four reading frames
d. It is one of two direct repeats present in the HBV genome
a. It is added by HBeAg and indicates active replication of HBV
What is a clinical feature of HBV infection?
a. 90% of those under 5years of age develop a chronic infection
b. Jaundice is observed in 30-50% of those over 5 years of age
c. The incubation period is about 10days
d. The fatality rate is 2-10% in those over 5 years of age
b. Jaundice is observed in 30-50% of those over 5 years of age
How does the typical serologic course of HBV differ between acute and chronic infections?
a. HBsAG persists throughout the acute infection
b. There is a steep decrease in total anti-HBc during an acute infection
c. The level of IgM anti-HBc persists during both infections
d. In a chronic infection, the HBeAg phase lasts longer than the anti-HBe phase
d. In a chronic infection, the HBeAg phase lasts longer than the anti-HBe phase
What is not a feature of HBV and liver cancer?
a. Hepatocellular carcinoma can develop in 2-10% of those infected with HBV
b. All of those with untreated HBV eventually develop hepatocellular carcinoma
c. It involves a random partial integration of the HBV genome
d. Mutations accumulate due to repeated destruction of regeneration of hepatocytes
b. All of those with untreated HBV eventually develop hepatocellular carcinoma
What allows HDV infection to develop?
a. It has a coat with HbsAg antigens and infects in conjunction with HBV
b. It can cause a coinfection with HBV that results in chronic HDV and severe chronic liver disease
c. It can cause a superinfection that results in sever acute disease but a low risk of chronic infection
d. It can “piggyback” HCV and lead to superinfection and chronic liver disease
a. It has a coat with HbsAg antigens and infects in conjunction with HBV
What is a feature of hepatitis C virus?
a. It is part of the caliciviridae family
b. It has a low mutation rate
c. It contains a self-replicating RNA replicon
d. It elicits a high immune response and resistance to super-infection
c. It contains a self-replicating RNA replicon
Which virus is a flavivirus and contains a lipid droplet in its capside?
a. HAV
b. HBV
c. HCV
d. HDV
c. HCV
What is involved in the clinical development and sequelae of HCV?
a. 70-90% of those infected develop a persistent infection
b. The incubation period is often years long
c. Jaundice is evident in 70% of cases
d. Cirrhosis and liver failure are rarely seen as a result of HCV infection
a. 70-90% of those infected develop a persistent infection
