Ebola (31) Flashcards
What is correct about the clinical features of Ebola?
a. Gastrointestinal symptoms occur after 3-10 days
b. Shock or recovery will occur after 3 days
c. Late complications are characterised by flu like symptoms
d. Meningoencephalitis can occur during the early febrile stage
a. Gastrointestinal symptoms occur after 3-10 days
What is FALSE about the West African Ebola outbreak?
a. Patient zero was a two year old boy in Guinea
b. The strain of Ebola showed no similarity to other ZEBOV strains
c. There have been about 28000 cases and 11000 deaths
d. 15 out of 20 initial samples were Ebolavirus PCR +ve
b. The strain of Ebola showed no similarity to other ZEBOV strains
What influenced the outcome of the West African Ebola outbreak?
a. It occurred within the known geographic range for Ebola
b. The affected areas had sufficient public health infrastructure
c. The initial response was ineffective
d. The outbreak was detected early
c. The initial response was ineffective
What is correct about the proteins encoded for by Ebola virus?
a. L and VP35 form the RdRp
b. VP30 and Vp24 form the matrix
c. VP40 is the capsid protein
d. NP and GP fuse to form glycoproteins
a. L and VP35 form the RdRp
In terms of Ebola virus replication:
a. It enters the cell by direct fusion using its GP glycoprotein
b. Replication occurs in the nucleus
c. NP mediates the switch to genomic replication
d. Virions assemble at the plasma membrane before the host cell undergoes apoptosis
c. NP mediates the switch to genomic replication
What is correct about Ebola virus virulence?
a. All strains are pathogenic to humans and at least 50% fatal
b. ZEBOV is more fatal and has a longer incubation period when acquired by direct contact as opposed to injection
c. SEBOV is non-human-pathogenic
d. The fatality of ZEBOV is 70-90% but can vary depending on the mode of transmission
d. The fatality of ZEBOV is 70-90% but can vary depending on the mode of transmission
What is correct about diagnosing Ebola virus?
a. Serology to target GP antigens is the gold standard and is sensitive and rapid
b. Saliva is often used as there is a low viral titre in the plasma
c. RT-PCR is the preferred method and detects SEBOV and ZEBOV specific GP, NP and L genes
d. Electron microscopy is required to definitely confirm Ebola virus diagnosis
c. RT-PCR is the preferred method and detects SEBOV and ZEBOV specific GP, NP and L genes
• Ebola first emerged in Zaire and Sudan in 1976 to respectively give rise to the ZEBOV and SEBOV strains.
T
• A big influence in the transmission of Ebola virus is zoonosis and the hunting and consumption of bush meat.
T
• ZEBOV is viable in tissue culture media on plastic slides for 4* for 50 days.
F (glass only)
• Because of its envelope, Ebola virus is not easily inactivated by chemicals.
F
• Primates may be susceptible to Ebola in aerosols, but there is no demonstration of the virus actually spreading in aerosols.
T
• Despite having a lot R0, Ebolavirus is classified as a level 4 agent because case fatality rate is high and there is an absence of vaccines and therapeutics.
T
• For virus transmission to be sustained, R0 cannot be greater than 1.
F
• There have been at least 50 documented instances of Ebola accidents in a diagnostic setting.
F
