Antiviral Drugs (19) Flashcards
Which drug is described correctly?
a. Amantadine is used in HIV infection to block Nef
b. Interferons are used to treat Herpesvirus
c. Fuzeon is a HIV fusion inhibitor
d. Ribavirin is a HIV protease inhibitor
c. Fuzeon is a HIV fusion inhibitor
What is a feature of using interferons as antivirals?
a. They have no side effects
b. They only work on RNA viruses
c. They specifically prevent viral penetration
d. They are delivered as purified recombinant proteins
d. They are delivered as purified recombinant proteins
What is amantadine?
a. It prevents entry and un-coating of influenza by inhibiting M2 ion channels
b. It prevents the acidification of neuraminidase during influenza uncoating
c. It binds to beta sheets in the M2 ion channel of influenza
d. It is a neuraminidase blocker used to treat influenza via inhalation
a. It prevents entry and un-coating of influenza by inhibiting M2 ion channels
What is T20?
a. A fusion inhibitor used to fight HIV
b. A potent nucleoside analogue
c. An inhibitor of HIV GP120
d. A inhaled neuraminidase inhibitor
a. A fusion inhibitor used to fight HIV
What is not a feature of acyclovir?
a. It is a prodrug
b. It is a guanosine analogue which lacks a 3’ OH group
c. It inhibits cellular DNA polymerase only
d. It is activated by viral HSV-TK
c. It inhibits cellular DNA polymerase only
Which is a pro-drug?
a. Tamiflu
b. Acyclovir
c. T20
d. Amantadine
b. Acyclovir
What is not a feature of Ribavirin?
a. The monophosphate form reduces nucleic acid synthesis
b. It can only be used for RNA viruses
c. The tri-phosphate form alters viral mRNA formation
d. It can be used against influenza and viruses that cause hemorrhagic fever
b. It can only be used for RNA viruses
What is a feature of zidovudine/AZT?
a. Cellular kinase phosphorylates it to AZT-triphosphate
b. It is a thymidine analogue that inhibits integrase activity
c. It promotes chain elongation
d. It has a low affinity for viral reverse transcriptase
a. Cellular kinase phosphorylates it to AZT-triphosphate
What is a feature of Non-Nucleotide Reverse Transcriptase Inhibitors for HIV-1 (NNRTI)?
a. They bind to the binding site of reverse transcriptase
b. They are RNA analgoues
c. They indirectly inhibit reverse trnasciptase
d. They do not have a close structural similarity to nucleotides
d. They do not have a close structural similarity to nucleotides
What is Raltegravir?
a. A HIV protease inhibitor
b. An integrase inhibitor that blocks strand transfer
c. A nucleoside analogue that terminates HIV strand transfer
d. An integrase inhibitor that catalytically processes the 3’ ends of viral DNA
b. An integrase inhibitor that blocks strand transfer
What is involved in HAART?
a. It requires that HIV patients take 25 pills a day
b. It cures HIV-induced immune dysfunction due to chronic immune activation
c. It can remove latent HIV infection
d. It minimises the chance of drug resistance arising
d. It minimises the chance of drug resistance arising
• Neuraminidase is enzymatically inactive.
F
• Relenza is taken orally and Tamiflu is inhaled.
F
• Tamiflu has a high affinity for the neuraminidase active site due to a hydrophobic group.
T
• R5 co-receptor anti-HIV drugs are most common due to the abundance of CCR5 and it’s presence on dendritic cells.
T
