hepatitis Flashcards
define hepatitis
inflammatory condition of the liver
most common viral cause of hepatitis
HAV, HBV, HCV< HDV, HEV
symptoms with acute hepatitis
- jaundice
- dark urine
- fatigue
- nausea
- vomiting
- abdominal pain
with what hepatitis is chronic hepatitis seen
HBV and HCV
hepatitis A
- infectious hepatitis
- most common
- nonenveloped RNA
- contaminated food and water
Hepatitis B
- both acute and chronic infections
- long term environmentally stable
- DNA virus
HBcAg
core virus
HBsAg
surface antigen on surface proteins
HBeAg
envelope antigen
what does the presence of HBsAg indicate
present before clinical symptoms start
Anti-HBs
hep B surface antibody
pos = aquired immunity
neg = inadequate immune response or lack of recovery
HBcAg
only present in nuclei of hepatocyte during acute infection
anti-HBc total
used for recent HBV infections
differentiates recent vs chronic HCV
anti-HBc IgM
specific for acute HBV infection
what do the results indicate
HBsAg pos
total anti-HBc pos
IgM anti-HBc pos
acute infection
what do the results indicate
HBsAG pos
total anti-HBc pos
chronic infection
results for chronic Hep B actively replicating
HBsAG pos
anti-HBs neg
anti-HBc total pos
HBeAg pos
anti-HBe neg
results for chronic hep B non replicating
HBsAg pos
Anti-HBs neg
Anti-HBc total pos
HBeAg neg
anti-HBe pos
hepatitis C
RNA
chronic
parentally transmitted
chronic HCV
develops in 80% of infected
anti-HCV by EIA detection then RNA
hepatitis D
delta hepatitis
defective RNA
requires HBV infection
difference between coinfection and superinfection
coinfection = at the same time
superinfection = D after B
hepatitis E
nonenveloped RNA
fecal-oral infection and waterborne
IgM diagnosis
which hepatitis is the only DNA virus
HBV
which hepatitis cannot form a chronic infection
hep A
