Hepatita cronica - generalitati Flashcards

1
Q

definitie hepatite cronice

A

procese necro-inflamatorii si fibrotice hepatice cu o evolutie de peste 6 luni

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2
Q

cele 4 sindroame biologice pentru evaluare biologica a afectarii hepatice

A

hepatocitolitic
hepatopriv
inflamator
bilioexcretor

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3
Q

Prin ce se face stadializarea hepatitei cronice?

A

biopsie hepatica

evaluare non-invaziva a fibrozei hepatice

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4
Q

makeri non-invazivi de determinare a fibrozei

A
fibrotest actitest
teste elastografice (fibroscan, ARFI, 2D-SWE)
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5
Q

Care sunt scorurile de incadrare histologica ale hepatitei cronice?

A

Knodell
Metavir
HAI

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6
Q

Ce evalueaza scorurile de incadrare histologica ale hepatitelor cronice?

A
activitatea necroinflamatorie (grading)
fibroza (staging)
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7
Q

Pentru ce se foloseste scorul Knodell?

A

necroinflamatie in hepatita cronica B

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8
Q

Pentru ce se foloseste scorul Metavir?

A

pentru necroinflamatie si fibroza in hepatita cronica C

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9
Q

Care este primul lucru care se face pentru determinare etiologiei in hepatita cronica?

A

cautarea markerilor virusali Atg HBs

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10
Q

Cand Atg HBs este pozitiv, ce urmeaza?

A

se vor cauta anticorpii anti-D si anti HCV

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11
Q

Daca Ac anti-D si anti HCV sunt negativi, ce urmeaza?

A

se vor cauta celelalte etiologii pisibile

  • hepatita autoimuna
  • boala Wilson
  • deficitul de alfa 1 antitripsina
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12
Q

Ce se dozeaza pentru hepatita autoimuna?

A
  • anticorpi antinucleari
  • LKM1
  • SMA (smooth muscle antibody)
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13
Q

Ce se dozeaza pentru boala Wilson?

A

ceruloplasmina

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14
Q

Ce se dozeaza pentru deficitul de alfa 1 antitripsina?

A

alfa 1 antitripsina

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15
Q

teste biologice sindrom hepatocitolitic

A

ASAT, ALAT crescute de 2-3 ori

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16
Q

teste biologice sindrom hepatopriv

A

scaderea IQ
scarea TQ
scaderea albuminemiei

17
Q

teste biologice sindrom bilio-excretor

A

cresterea bilirubinemiei