Hepatita cronica cu virus C Flashcards

1
Q

transmitere VHC

A

orizontala

verticala

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2
Q

Cum determina VHC leziuni hepatocitare?

A
  • actiune toxica virala directa

- mecanism mediat imunologic

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3
Q

tablou clinic hep cron C

A
  • cel mai adesea sters sau absent

- astenie nejustificata

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4
Q

evaluare biologica hep cron c

A
  1. pe cele 4 sindroame
  2. se cauta etiologia
  3. se face viremia
  4. se eval leziunile extrahepatice
  5. verificam si hepatita autoimuna
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5
Q

Ce se foloseste pentru stabilirea etiologiei in hep cron C?

A

anticorpi anti HCV prin tehnici ELISA de generatia III

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6
Q

Cum ne dam seama ca avem o infectie activa cu VHC?

A

antiHCV + transaminaze modificate

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7
Q

Prin ce se face viremia in hep cron C?

A

PCR ARN HVC

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8
Q

Cum se evalueaza leziunile extrahepatice in hep cron C?

A
  • det crioglobuline
  • proteinurie
  • sediment Addis
  • clearence cu creatinina
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9
Q

Pentru ce se foloseste sedimentul Addis?

A

det hematiilor in urina

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10
Q

Cum verificam hepatita autoimuna?

A

ANA
LKM1
SMA

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11
Q

Prin ce se evalueaza morfologic hep cron C?

A

biopsie hepatica

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12
Q

Cum arata hep cron C la microscop?

A
  • leziuni lobulare
  • steatoza
  • corpi Mallory
  • proces necroinflamator
  • ARN VHC in hepatocitele afectate
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13
Q

Pe ce se face dx hep cron C?

A
  • tablou clinic
  • explorare biologica
  • explorare etiologica
  • stadialiare histologica
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14
Q

cx hep cron C

A
  • ciroza
  • hepatocarcinom
  • purpura
  • glomerulonefrita
  • alte afectiuni autoimune
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15
Q

tipuri de tx mx hep cron C

A

terapie bazata pe interferon

terapie orala interferon free

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16
Q

descrie tx bazata pe interferon in hep cron C

A

PegInterferon + Ribavirina 48 saptamani

17
Q

descrie tx interferon free in hep cron C

A

medicamente cu actiunie antivirala

  • sofosbuvir
  • ledispavir