Hepatita cronica cu virus B Flashcards

1
Q

Care este sursa principala de infectie in hepatita cronica cu virus B?

A

sangele infectat

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2
Q

Care sunt caile de transmiere a virusului HBV?

A
orizontala
-parenteral/percutan
-contact fizic non-sexual
-contact sexual
verticala
-perinatala
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3
Q

Ce produce virusul HB replicandu-se in hepatocit?

A

cantitati mari de AgHBs

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4
Q

markeri serologici hepatita B

A
  • Atg HBs
  • Atg HBe
  • Anti HBs
  • Anti HBe
  • DNA HBV
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5
Q

descrie Atg HBs

A
  • apare atat in faza acuta cat si cronica

- prezenta peste 6 luni dupa o hepatita acuta arata cronicizarea

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6
Q

descrie Atg HBe

A

=faza replicativa a infectiei

-semnifica infectia cu virus salbatic

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7
Q

descrie Anti HBs

A

=imunizarea prin infectie/vaccinare

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8
Q

descrie Anti HBe

A

-apare in momentul seroconversiei AgHBe/antiHBe

=imbunatatirea prognosticului

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9
Q

descrie DNA HBV

A

=replicare virusala

-aprecierea progresivitatii hep cron B

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10
Q

Care este primul element pe care il cautam la o hepatita cronica?

A

Atg HBs

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11
Q

Daca Atg HBs este pozitiv, ce urmeaza?

A

vom cauta daca este un virus salbatic sau mutant si replicarea virala

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12
Q

Ce arata ca este un virus salbatic in hep cron B?

A

Atg HBe

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13
Q

Ce arata ca este un virus mutant in hep cron B?

A

Anti HBe pozitiv sau ADN VHB cu Anti HBe negativ

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14
Q

Ce ne arata replicarea virala in hep cron B?

A

DNA HBV

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15
Q

tablou clinic hep cron B

A
  • transaminaze crescute
  • hepato- +/- splenomegalie
  • rar icter/subicter
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16
Q

tablou biologic hep cron B

A
sdr hepatocitolitic
-ASAT ALAT 2-3xN
sdr inflamator
-PCR, VSH
sdr bilioexcretor
-cresterea bilirubinei (rar)
sdr hepatoriv
-putin modificat
17
Q

Care sunt cele doua forme de hep cron B?

A

forma e pozitiva
= Atg HBe pozitiv
forma e negativa
= Atg HBe negativ, DNA HBV pozitiv

18
Q

Prin ce se face stadializarea hep cron B?

A

biopsie hepatica

teste non-invazive

19
Q

Cu ce se coloreaza hep cron B?

A

orceina

20
Q

Cum arata hep cron B la microscop?

A

hepatocite cu aspect de sticla mata

21
Q

Ce este absolut contraindicat in hep cron B?

A

consumul de alcool

22
Q

Cum se numeste vaccinul pt hep cron B?

A

Engerix B

23
Q

Unde se face vaccinul pt hep cron B?

A

in muschiul deltoid

24
Q

mx hep cron b

A

antivirala

  • interferon (peginterferon)
  • analogi nucelozidici (entecavir, tenofovir)