Hepatic Flashcards
What mutation is associated with copper hepatopathy in Bedlington terriers?
COMMD1, autosomal recessive.
What mutation is associated with copper hepatopathy in Bedlington terriers?
COMMD1, autosomal recessive.
What was the sensitivity of ALT for acute and chronic hepatitis (respectively) in Labradors?
JVIM 2017: 45% for acute, 71% for chronic
What may microRNA panels be used for in liver disease?
JVIM 2018: mi 122 can be used to diagnose liver dz; Sn 77 and Sp 97
JVIM 2016: panel may be used, as associated with various liver diseases; miR 126 - chronic hepatitis, mi 200 - HC carcinoma, mi 21 and 222 - GB mucocoele
Can plasma glutathione concentrations predict levels in the liver?
JVIM 2019 - No
What was the diagnostic agreement of punch, cup and needle biopsies compared to wedge for the liver?
JVIM 2015: Agreement in 60-69% depending on method
JVIM 2018: Compared 3mm to 5mm cup; 67-69%
Biopsy of 2 liver lobes identified the predominant histologic abnormality in what % of cases?
JVIM 2015: 98.6%. only 56% of dogs had 6/6 lobes have the same diagnosis. Samples of several lobes is recommended
What is the interobserver agreement like for liver histology?
JVIM 2017: Fair for fibrosis but poor for necroinflammatory. They recommended 1+ pathologist evaluate sections
What is the association between gall bladder ultrasound findings and the results of bile bacterial culture?
JVIM 2017: Abnormal GB ultrasound was Sn (96%) but not specific (49%) for positive culture in cats. In dogs Sn was 81% and Sp 31% (poorer)
what is perflubutane? what could it be used to differentiate in dogs with liver disease?
JVIM 2017: A second generation ultrasound contrast agent. Phagocytosed by Kupffer cells - the washout ratio of this agent in the hepatic vein was able to predict hepatitis with Sn of 100 and Sp 85% (decreased - perhaps from Kupfer cell impairment)
What is the impact of obesity on the liver biochemically and on ultrasound?
JVIM 2018: Associated with higher ALP and GGT. Obese dogs also had abnormal hepatic spectral wave
What risk factors are associated with urolithiasis in PSS dogs? Is shunt morphology a factor?
JAVMA 2015: Morphology not a factor. Being older, male and having received prior medical therapy were risk factors
What were risk factors identified for a positive bacterial bile culture in dogs?
JAVMA 2015: Dashchunds over represented. Dogs with positive culture were more likely to have biliary sediment or sludge
What biochemical marker was associated with a positive bile culture in a 2016 JVIM study? What had higher yield for microorganisms, cytology or culture?
CPLI. Cytology
What has a higher yield for eggs for Platynosomum; bile or faeces?
JVIM 2016: Bile
Can a patient have a normal serum bilirubin with a ruptured gall bladder?
JAVMA 2015; yes, so GB rupture remains a ddx for acute abdomen even in non-icteric dogs
What is the mortality rate for elective cholecystectomy compared to non-elective?
JAVMA 2018; 2% compared to 20%