Cardiovascular Flashcards
What is the significance of atrial fibrillation for dogs with MMVD and CHF, over 15kg
Jung JVIM 2015: AFIb dogs had a shorter MST (142 vs 234) and increased risk of cardiac related death. Rate control improved MST. Combination treatment significantly decreased HR and prolonged MST compared to diltiazem alone
Can cardiac troponin I b used as a prognostic indicator in SIRS?
Hamacher JVIM 2015: Negative prognostic indicator at admission, no further information from sequential monitoring
What are the three troponin subunits and what is its function?
I, C and T. This complex controls cardiomyocyte contraction. T secures to the thin filament. I is inhibitory and C binds calcium when contraction is initiated
Can proBNP measurement be affected by strenuous exercise in dogs?
Hunt JVIM 2018: Yes
What are microRNA and what might they be useful for?
JVIM 2020 upregulation in one microRNA with doxorubicin, preceding troponin. Potential biomarker. MicroRNA bind RNA and prevent signal translation. They are also very stable
What is the MOA and indication for fenoldopam?
dopamine-1 agonist action, fenoldopam causes renal arterial vasodilation, natriuresis, and increased GFR in normal dogs. Anti-hypertensive
What drugs could be indicated for a hypertensive emergency and what is their MOA?
Fenoldopam - dopamine 1 agonist
Hydralazine (0.5-2 mg/kg PO q12h) has a rapid onset of action and can be used for rapid reduction of BP in both cats and dogs; direct acting smooth muscle relaxant. Inhibits calcium release within the muscle
What is the difference between coccygeal and radial artery doppler blood pressure measurement in cats?
JAVMA 2017: Coccygeal not affected by age or muscle condition. Radial affected by muscle condition. Mean systolic coccygeal pressures higher than radial (+19mm), though this is not consistent. Paper recommended coccygeal measurement and MCS monitoring
JFMS 2018; Also found significantly higher systolic BP in the tail. Obesity increased difference between. This study critiqued JAVMA 2017 saying cannot preference coccygeal over radial, as precision of radial is still high and no studies to support difference being pathological
Are there any biomarkers which are useful diagnostic tests for hypertension in cats? Are any biomarkers associated with hypertension in cats?
Bijsmans JVIM 2017: No. VEGF was higher in hypertensive cats with ocular TOD and was independently predictive of hypertension. CTnI was also independently predictive of hypertension. Based on ROC none useful as a diagnostic test though.
What is the effect on NT-proBNP when treating hypertension in cats? What about troponin and VEGF?
Bijsmans JVIM 2017. NT-ProBNP decreased with treatment of hypertension. Troponin and VEGF did not
What factors influence the required amlodipine dose for a hypertensive cat?
Bijsmans JVIM 2016: pre-treatment blood pressure
What is the frequency of hypertension developing in dogs treated with toceranib?
Tjostheim JVIM 2016; 37% of treated dogs developed SBP ≥ 160 mmHg
What is the frequency of hypertension developing in dogs treated with toceranib?
Tjostheim JVIM 2016; 37% of treated dogs developed SBP ≥ 160 mmHg
What is the effect of telmisartan on blood pressure in hypertensive cats?
Glaus JVIM 2018: Evaluated telmisartan in cats with SBP between 160-200mmHg. Was effective at reducing BP by 19.2mm at 2 weeks and 24.6mm at 4 weeks. 52% of cats treated were <150 at 4 weeks
Coleman JVIM 2018: at 4 weeks reduced SBP by 23.9mmHg and effect persisted over 6 months
What trend is seen with Vitamin D concentrations in dogs with degenerative valvular disease?
Serum 25(Oh)D concentrations are significantly lower in B2 compared to B1. No significant difference between B2 and C/D
How do leptin and adiponectin change with MMDV.
Kim JVIM 2016. Lepin high and adiponectin low compared to healthy dogs. ISACHC Class 3 (severe HF) dogs had high leptin concentrations, as well as adiponectin, compared to Class 1 dogs
What serum factor and signalment characteristics can affect markers of oxidative stress in dogs with MMVD?
Reimann JVIM 2017. OxLDL, Vitamin E, Y-tocopherol are affected by sex, BCS, neuter status and cholesterol. Could not be used for clinical stage of MMVD in this study
What is angiotensin converting enzyme 2 and what is its purpose?
Angiotensin-converting enzyme 2 (ACE2) is a homologue of angiotensin-converting enzyme (ACE) and produces angiotensin peptides (APs), such as angiotensin 1-9 and 1-7 that are vasodilatory and natriuretic, and act to counterbalance angiotensin II
Larouche JVIM 2019: In CHF, ACE-2 and beneficial products AG 1-7 are increased
What are the actions of Angiotensin 2? What receptor does it act on?
acts on angiotensin receptor type 1 and causes potent vasoconstric- tion, sodium and water conservation, aldosterone release, and myocar- dial remodeling
What is TMAO? What is its significance in heart disease?
Karlin JVIM 2018; an oxidised product of trimethylamine, which is produced by GI bacteria when they metabolise choline. Was found to be increased in dogs with CHF secondary to DMVD compared to subclinical dogs and healthy controls
What is speckle tracking echocardiography?
Toaldo JVIM 2017; 2D method using speckle tracking to calculate regional myocardial deformation and therefore function. In this study showed that LA function reduces with progression of MMVD. It was found to be feasible and reproducible.
What echocardiographic variable has prognostic significance in dogs with MMVD?
Toaldo JVIM 2017; several in an univariate analysis. In multivariate just the MV E wave velocity. An increase in MV E vel is an indirect measure of mitral regurgitation severity, reflecting worsening pressure differences between the LA and LV with increasing regurgitant volumes.
Nakamura JVIM 2016: Right ventricular Tei-index has a strong correlation with the prognosis for dogs with MMVD. The most significant independent predictor of death was RVTX in this study. La:Ao was also predictive
The Tei index (TX), also known as the myocardial performance index, is an index of global myocardial function, including systolic and diastolic performance. It is calculated by dual pulsed wave doppler
What is the impact of disease class and pulmonary hypertension on right heart function in MMVD?
Toaldo JVIM2016: not able to identify a significant deterioration of RV systolic or diastolic function with the progression of severity class in dogs with naturally occurring MMVD and different degrees of PH. Chapel JVIM 2018: RV systolic function was increased in B2 MMVD but then decreased in stage C.
What can the pulmonary vein to artery ratio be used to predict?
Merveille JVIM 2015: CHF in MMVD. The presence of CHF could be best predicted by measuring PV/PA in 2D echocardiography cut-off, 1.7
What tissue doppler echocardiographic finding can be used to predict CHF in MMVD?
Kim JVIM 2015: TDI-derived E/Em sept which evaluates diastolic function could be an important predictor of CHF in dogs with MMVD and it may overcome the limitation of load-dependent conventional echocardiography.
What echo findings can be used to predict cardiac death later in life in CKCS?
Reimann JVIM 2017. Moderate to severe MR, even if intermittent, and increased LVIDSN in dogs <3 years of age were associated with cardiac death later in life in CKCS. Males had higher all cause mortality with MR.
How to the MV differ between healthy CKCS and other breeds?
Manicotti JVIM 2018: CKCSs having a flatter MV with reduced tenting, compared to the MV of other breeds.
In the EPIC study, what was the effect of Pimobendan vs Placebo?
Median time to primary endpoint was 1228 days (95% CI: 856–NA) in the pimobendan group and 766 days (95% CI: 667–875) in the placebo group (+15 months)
Dogs in the pimobendan group lived longer (median survival time was 1059 days (95% CI: 952–NA) in the pimobendan group and 902 days (95% CI: 747–1061) in the placebo group) (P = .012)
Dogs receiving pimobendan had approximately two-thirds the risk of reaching the primary end- point compared with dogs on placebo
TEST study; how did torsemide compare to frusemide?
The present trial demonstrates that torasemide q24h is noninferior to furosemide q12h when considering a composite clinical score endpoint (% treatment success; clinical and TXR pulmonary oedema). Torasemide was associated with a 2-fold reduction in the risk of reaching the secondary composite cardiac endpoint “spontaneous cardiac death, euthanasia for HF, or CHF class worsening” over a 3-month period
Does treatment for CHF reduce NT pro-BNP?
Hezzell JVIM 2018: A pre defined treatment algorithm in response to BNP measurements was able to reduce BNP in stable MMVD dogs with CHF
What is the MOA of sacubitril/valsartan? What is its effect in Stage B2 MMVD dogs (clue; decreased what in urine)?
ARB/NEP inhibitor. NEP (Neprilysin) cleaves natriuretic peptides that are meant to protect against RAAS activation. It can decrease urinary aldosterone/creatinine ratios
In the second part of EPIC, what pathological variables did Pimobendan affect, and what did this predict?
Pimobendan reduced heart size in dogs with B2 MMVD and this was associated with increased time to CHF and cardiac related death. LV end systolic dimension was associated with therapeutic benefit. At the onset of CHF, groups were similar.
What is the effect of a single dose of BNP1-32 on dogs with Stage C MMVD
BNP1-32 was well tolerated, and after subcutaneous dosing, it was well absorbed and resulted in an increase in UEcGMP (mediator of activity); however, there were no measurable effects on biological outcomes (UOP, BP, HR, FENa/K, and plasma aldosterone concentra- tion) in this study.
What is the dose-response relationship for ACEi in dogs with cardiac disease?
Ward JVIM 2021: q 12 hour dosing and higher potassium at the first revisit was predictive of 2 year survival
How do you measure LA size on x-rays? Does this correlate with La Ao?
Malcolm JAVMA 2018; Measure from carina to the caudal aspect of the LA where intersects with the CVC. Measure vertebra forward from T4. >2.3 predictive of LA enlargement. Useful measurement based on this study
How do you measure LA size on x-rays? Does this correlate with La Ao?
Malcolm JAVMA 2018; Measure from carina to the caudal aspect of the LA where intersects with the CVC. Measure vertebra forward from T4. >2.3 predictive of LA enlargement. Useful measurement based on this study
What are the pathologic changes seen in the LA and LV with MMVD?
Lee JVIM 2015: LA degenerates more severely, fatty change, immune cell infiltration and fibrosis. LB hypertrophied. LV end diastolic dimension/ejection fraction was associated with fatty replacement and vacuolisation.
What is the prevalence and risk factors for degenerative mitral valve disease in dogs in primary care in England?
Estimated prevalence 0.36% of diagnosed MMVD. Males, insured, <20kg, geriatric, CKCS, Chihuahua,, Whippet, Poodle
Can a breeding scheme reduce the risk of MMVD in CKCS?
Birkegard JVIM 2016; yes, breeding scheme over 8-10 year period reduced risk by 73%
What is the prognosis after diagnosis of “advanced” heart failure.
Beaumier JVIM 2018. median duration between the diagnosis of stage C and advanced heart failure was 163 days, and the median survival time after the diagnosis of advanced heart failure was 281 days. Higher frusemide dose and non hospitalisation were associated with longer survival. 81% of dogs had an increased BUN and 76% of dogs with hypochloremia at some point during treatment.
What factors were associated with disease progression from Stage B MMVD in a UK study?
Mattin JVIM 2018; Plasma NT-proBNP, heart rate, heart murmur intensity, presence of a cough, being a Cavalier King Charles Spaniel, and being prescribed pimobendan were associated with clinical progression to initiation of treatment with a potent diuretic or cardiac-related death