Hemostasis - Unit 3 Flashcards
What is hemostasis?
Blood stagnation/the process of clot formation.
In simple terms, how does this work?
Tissue injury —> Platelet Plug —> Biochemistry –> Clot
When an injury occurs, what factor affects the common pathway?
Factor 10
Factor 10 (X) - what happens after this?
Prothrombin –> Thrombin –> Fibrinogen –> Fibrin –> Clot
Why does the coagulation process matter?
Because lots of drugs we give affect this!
Bleeding & Clotting Disorders - Platelet Issue or Factor Issue - T/F?
True!
What are the platelets? How do they act in a bleed?
First responders, unstable platelet plug, they trigger clot formation, and repair microvascular injuries.
Is a platelet plug very stable?
Not at all - it tends to go away within an hour. It’s easy to break away - it does this because it signals the body to create a clot.
Thrombocytopenia - def
Low Platelet
Thrombocytosis/thrombocythemia - def
high platelet count - not general symptomatic.
Von Willebrand Factor (vWF) deficiency - what is it?
A platelet or factor problem.
What is Von Willebrand disease?
Typically, it gets platelets to adhere to site of injury. It activate them.
In this disease, inadequate/ineffective vWF reduces platelet adhesion, activation and aggregation.
What are some signs and symptoms of platelet problems?
Nosebleeds (epistaxis), Bleeding gums, Heavy menstrual bleeding, bruising, melena (black/bloody stool), symptoms of anemia.
What are some treatments for Thrombocytopenia/VWD?
SAFETY FIRST!!!
Prevent blood loss. We might need to do a transufsion, DDAVP, immunosuppresant drugs, plasmapheresis.
What does DDAVP (Desmopressin) do for blood?
At what level do we usually transfuse? Are we careful with it?
If you have any VWF, it releases it!