HEMOSTASIS Flashcards
function of the plasma proteins?
transport
antibodies
osmotic regulation
blood clotting
what are the types of plasma proteins based on the chart?
albumin
globulins
A1 lipoproteins
fibrinogen
globulins divided up into:
A1,A2, B1, antibodies
a2:
a2 glycoproteins
ceruloplasmin
prothrombin
B:
B1 lipoprotein
transferrin
plasminogen
antibodies:
IgA
IgG
ETC
what are the lipid transport proteins?
alpha 1 lipoprotein
beta 1 lipoprotein
what are the blood clotting proteins?
fibrinogen
plasminogen
prothrombin
what are the specific transporters?
transferrin
ceruloplasmin
the types of antibodies?
gamma globulins
• HDLs present in the blood at concentrations of 350-450 mg%
• 40-70% of the structure is lipid with remainder being apoprotein
• Functions:
o Scavenge cholesterol
o Donate apoprotein to VLDLs and chylomicrons
α1- lipoproteins
• LDLs present at similar concentrations to HDLs
• Huge size with molecular weight of up to 20 mil
• 80-90% of LDL is lipid with apoprotein as the rest
• Function:
o Lipid transport for FFA donation to tissues (particularly adipocytes)
β1-lipoprotiens
- Very large glycoprotein present in blood at concentrations of 300 mg%
- Precursor for fibrin which forms the mesh that hold clot together (function)
Fibrinogen
- Intermediate sized protein present at low concentration
* Precursor for fibrinolysin which dissolves clots (function)
Plasminogen (β)
- Small glycoprotein
* Precursor for thrombin, which is important in triggering fibrin mesh formation (function)
Prothrombin (β)
- Intermediate sized glycoprotein present at ~40 mg %
* Function: transport iron in blood
Transferrin
- Similar in size and concentration to Transferrin
* Function: copper transport
Ceruloplasmin
4 phases of hemostasis
vascular phase
platelet phase
coagulation phase
fibrinolysis phase
vasoconstriction, we see decrease in blood loss by lowering pressure? T/F
T