ALLOSTERIC NATURE OF HB BINDING Flashcards
shift to right means?
harder to find O2 to Hb and Hb will release O2 more easily
shift to left means?
easier to saturate Hb with O2 in lungs and unload it at the tissues
shift to right is caused by?
increased blood acidity
increased blood PCO2
increased blood 2,3-DPG
increased by body temp
low pH and high PCO2 produce what type of effect?
Bohr effect
what is the effect of the Bohr effect?
easier to saturate Hb with O2 and harder for the Hb to let go of O2
shift to left is caused by?
decreased blood acidity (pH of 7.6 or higher)
decreased blood PCO2
fetal Hb
what can we note from fetal Hb?
has a more left shifted curve than adult Hb
needed so fetus can get O2 from mother circulation
fetal Hb doesn’t release O2 as easily
what is the binding coefficient of carbon monoxide vs oxygen to Hb?
250x greater than O2
*CO at 0.4 mmHg will compete equally with O2 at 105 mmHg and above that will cause more CO to bind than O2
what does PCO have to be at in order to be lethal?
0.7 mmHg
how can O2 out compete CO? adding in some CO2 helps by?
increasing PO2 allows O2 to win
increasing ventilatory drive