ALLOSTERIC NATURE OF HB BINDING Flashcards

1
Q

shift to right means?

A

harder to find O2 to Hb and Hb will release O2 more easily

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2
Q

shift to left means?

A

easier to saturate Hb with O2 in lungs and unload it at the tissues

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3
Q

shift to right is caused by?

A

increased blood acidity
increased blood PCO2
increased blood 2,3-DPG
increased by body temp

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4
Q

low pH and high PCO2 produce what type of effect?

A

Bohr effect

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5
Q

what is the effect of the Bohr effect?

A

easier to saturate Hb with O2 and harder for the Hb to let go of O2

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6
Q

shift to left is caused by?

A

decreased blood acidity (pH of 7.6 or higher)
decreased blood PCO2
fetal Hb

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7
Q

what can we note from fetal Hb?

A

has a more left shifted curve than adult Hb
needed so fetus can get O2 from mother circulation
fetal Hb doesn’t release O2 as easily

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8
Q

what is the binding coefficient of carbon monoxide vs oxygen to Hb?

A

250x greater than O2

*CO at 0.4 mmHg will compete equally with O2 at 105 mmHg and above that will cause more CO to bind than O2

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9
Q

what does PCO have to be at in order to be lethal?

A

0.7 mmHg

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10
Q

how can O2 out compete CO? adding in some CO2 helps by?

A

increasing PO2 allows O2 to win

increasing ventilatory drive

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