ALLOSTERIC NATURE OF HB BINDING

Question 1

shift to right means?

Answer 1

harder to find O2 to Hb and Hb will release O2 more easily

Question 2

shift to left means?

Answer 2

easier to saturate Hb with O2 in lungs and unload it at the tissues

Question 3

shift to right is caused by?

Answer 3

increased blood acidity
increased blood PCO2
increased blood 2,3-DPG
increased by body temp

Question 4

low pH and high PCO2 produce what type of effect?

Answer 4

Bohr effect

Question 5

what is the effect of the Bohr effect?

Answer 5

easier to saturate Hb with O2 and harder for the Hb to let go of O2

Question 6

shift to left is caused by?

Answer 6

decreased blood acidity (pH of 7.6 or higher)
decreased blood PCO2
fetal Hb

Question 7

what can we note from fetal Hb?

Answer 7

has a more left shifted curve than adult Hb
needed so fetus can get O2 from mother circulation
fetal Hb doesn’t release O2 as easily

Question 8

what is the binding coefficient of carbon monoxide vs oxygen to Hb?

Answer 8

250x greater than O2

*CO at 0.4 mmHg will compete equally with O2 at 105 mmHg and above that will cause more CO to bind than O2

Question 9

what does PCO have to be at in order to be lethal?

Answer 9

0.7 mmHg

Question 10

how can O2 out compete CO? adding in some CO2 helps by?

Answer 10

increasing PO2 allows O2 to win

increasing ventilatory drive