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CVRH Exam 1 > Hemostasis > Flashcards

Hemostasis Flashcards

1
Q

What is endothelin?

A

Vasoconstriction

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2
Q

What does the endothelial tissue release initially in damage?

A

Endothelin

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3
Q

What is the primary hemostatic plug?

A

Platelet adhesion and aggregation

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4
Q

What is the secondary hemostatic plug?

A

Activation of clotting cascade

Thrombin activation and fibrin network

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5
Q

What is the final step in hemostasis?

A

Fibrinolysis: breaking down of the scab

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6
Q

What do the platelets in the primary plug bind to?

A

Collagen

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7
Q

What is needed for platelets adhere?

A

Glycoproteins
von Willebrand factor
Collagen

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8
Q

What induces conformational changes in platelets?

A

ADP and thromboxane A2

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9
Q

How does aspirin stop clotting?

A

Inhibiting thromboxane A2

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10
Q

What is the intrinsic pathway?

A

Only involves factors in vasculature

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11
Q

What is the extrinsic pathway?

A

Only involves factors outside the vasculature

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12
Q

First factor in intrinsic pathway

A

Factor XII

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13
Q

First factor in extrinsic pathway

A

Tissue factor

Factor VII

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14
Q

What is needed for an intrinsic response?

A

Net negative charge on the endothelium

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15
Q

What does Coumadin do?

A

Blocks vitamin K synthesis

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16
Q

What does vitamin k do?

A

Cofactor in enzymes needed for post-trans mods on factors 2 7 9 10

17
Q

What does the partial thromboplastin time (PTT) assay test?

A

Measures activity of proteins in intrinsic pathway

18
Q

What does the prothrombin time (PT) assay test?

A

Measures activity of proteins in extrinsic pathway

19
Q

What do the tests not tell?

A

Which clotting factor specifically are deficient

20
Q

What does thrombin do?

A

Cleaves fibrinogen to form fibrin
Activates platelets
Pro-inflammatory effects

21
Q

What is unique about thrombin?

A

Can be pro or anti coagulation

22
Q

How do you prevent thrombosis?

A

PGI2, NO, and ADPase

CVRH Exam 1 (19 decks)

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