Autonomic LO Drugs

Question 1

Clonidine

Answer 1

Works on imidazole 1 and alpha-2 receptor in brain more effective anti-hypertension

Question 2

Methyldopa

Answer 2

False transmitter in brain alpha-2 receptor selector; pregnant; decrease hypertension

Question 3

Amphetamine

Answer 3

Increased norepinephrine release decreased dopamine reuptake TAAR1 activation

Question 4

Guanethidine

Answer 4

Releases all the store of norepinephrine; cannot be stimulated by nerves

Question 5

Reserpine

Answer 5

Destroys VMAT; norepinephrine cannot be reuptaken

Question 6

Tricyclic antidepressants

Answer 6

Inhibits NAT; cannot up take norepinephrine

Question 7

Tyramine

Answer 7

Uptaken by NAT; acts like norepinephrine

Question 8

Phenoxybenzamine

Answer 8

Non-selective; non-competitive inhibitor of alpha-1 and alpha-2

Question 9

Prazosine

Answer 9

Selective inhibitor of alpha-1

Question 10

Organophosphate treatment?

Answer 10

Pralidoxime atropine

Question 11

Ganglionic blocker in therapy

Answer 11

Trimethaphan

Question 12

Phentolamine

Answer 12

Non-selective competitive inhibitor alpha and alpha-2