Autonomic Drugs 3

Question 1

What in NET?

Answer 1

Neuronal amine uptake

Question 2

What does NET do?

Answer 2

Re-uptake of norepinephrine from the synaptic cleft

Question 3

What does VMAT do?

Answer 3

Breaks down monoamines depleting neurons of neurons of norepinephrine

Question 4

What affect do cocaine and tricyclic antidepressants cause?

Answer 4

Inhibit NET

Question 5

What affect does reserpine have?

Answer 5

Inhibits VMAT

Question 6

Drugs that end in -olol and are A-M are what?

Answer 6

Selective B1 blockers

Question 7

Drugs that end in -olol and are N-Z are what?

Answer 7

Non selective B blockers

Question 8

What does long term use of beta blockers cause?

Answer 8

Up regulation of beta receptors causing drugs to be more potent

Question 9

What does high lipid solubility cause in beta blockers?

Answer 9

High first pass liver extraction and metabolism and short plasma half life

Question 10

What beta blocker do you use for aortic dissection?

Answer 10

Esmolol

Question 11

What do amphetamine, methamphetamine and methylphenidate increase?

Answer 11

TAAR1 receptor which are associated with addiction

Question 12

What beta blocker is administered to pregnant women?

Answer 12

Methyldopa

Question 13

How is guanethidine taken up by pre-synaptic membranes?

Answer 13

NAT

Question 14

What does guanethidine cause?

Answer 14

Depletes norepinephrine from pre synaptic cleft

Question 15

What do tricyclines affect?

Answer 15

Only alpha receptors so heart is not affected