Drugs to Treat the Blood Disorders Flashcards
What are the two storage forms of iron?
Ferritin: water soluble Fe3+ (releases iron in controlled fashion)
Hemosiderin: particulate insoluble
What is the major way that iron is lost in the body?
Bleeding
What is the most efficient drug to replace iron intravenously?
Iron dextran (ferric iron)
What form of iron is absorbed best in the intestines?
Ferrous (Fe2+)
What form of iron is best used IV?
Ferric (Fe3+)
Is IV or oral iron supplements safer?
Oral
What affect on mitochondria can excess iron have?
Acidosis
Ferric iron can react with water and for Fe(OH)3 and hydrogen ion
What is an important iron chelator?
Desferoxamine
How does desferoxamine work?
Binds Ferric iron disallowing it to react with other compounds in the body
What are the two treatments for chronic iron toxicity?
Primary: bloodletting
Secondary: desferoxamine
What is epoetin alfa?
A erythropoietin analog made by recombinant DNA technology (glycosylated so longer half-life)
What is darbepoetin?
A erythropoietin analog that is even more glycosylated and thus more stable
What are two myeloid growth factors?
Filgrastim (G-CSF)
Sargramostim (GM-CSF)
What is oprelvekin?
Recombinant form of IL-11 produced in E. coli; increases platelet formation in chemo patients
What is romiplostim?
Small peptide linked to human Fc Ab segments; stimulates thrombopoeitin
