HEMOSTASE Flashcards
What is the definition of hemostasis?
Ensemble des phénomène physiologique qui concourent à la prévention et à l’arrêt des saignements
Hemostasis plays a crucial role in vascular integrity and repair.
What are the three stages of hemostasis?
- Hémostase primaire
- Coagulation plasmatique
- Fibrinolyse
What occurs during primary hemostasis?
- Vasoconstriction
- Formation of the platelet plug (thrombus blanc)
- Activation of coagulation factors on the surface of the platelet plug
What is the role of the von Willebrand factor in hemostasis?
Il se colle au collagène et aux plaquettes, permettant l’agrégation plaquettaire
Fill in the blank: The primary activator of coagulation is _______.
[facteur tissulaire]
What does thrombin do in the coagulation cascade?
- Recruits more platelets
- Activates the coagulation cascade
- Creates a loop of amplification
True or False: In vivo, factor XII is essential for coagulation.
False
What are the inhibitors of the coagulation cascade?
- Antithrombine
- Héparine et HBPM
- Système Prot C et Prot S
- TFPI
What is the purpose of pre-analytical steps in hemostasis testing?
Assurer la qualité et la précision des échantillons de sang pour les tests de coagulation
What anticoagulant is commonly used for blood sampling in hemostasis testing?
Citrate de sodium
What is the normal platelet count range?
150-400 G/L
What does TCA stand for in coagulation testing?
Temps de céphaline activé
What is the purpose of D-dimer testing?
Marqueur indirect de la fibrinolyse, utilisé pour exclure des conditions comme l’embolie pulmonaire
What are the two main pathways of coagulation?
- Voie extrinsèque
- Voie intrinsèque
Fill in the blank: The anti-aggregant that irreversibly inhibits COX1 is _______.
[Aspirine]
What are the indications for using heparin?
- Traitement des accidents thromboemboliques
- Prévention de la thrombose veineuse profonde
- Circuits d’hémodialyse
What does INR stand for?
International Normalized Ratio
What is the effect of vitamin K antagonists on coagulation factors?
Ils diminuent les facteurs de coagulation dépendants de la vitamine K (II, VII, IX, X)
True or False: Heparin has a direct effect on factor IIa (thrombin).
True
What is the primary function of anti-platelet agents?
Prévenir la formation de caillots artériels
What is the role of fibrin in hemostasis?
Cimente le clou plaquettaire
What is the significance of the complex prothrombinase?
Il joue un rôle clé dans la transformation de la prothrombine en thrombine
What happens to the TCA ratio if there is a deficiency in coagulation factors?
Il sera allongé
Qu’est-ce que l’indication HBPM ?
Utilisation de l’héparine de bas poids moléculaire dans des cas spécifiques
HBPM est utilisé pour des indications variées, notamment en cas d’insuffisance rénale.