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A_First Aid Random Memorizing > Heme Onc > Flashcards

Heme Onc Flashcards

1
Q

cell marker for hematopoetic stem cell

A

CD34

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2
Q

lines of zahn

A

thrombosis (fibrin lines with RBCs in between them)

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3
Q

marker for immature neutrophils

A

decreased Fc and decreased CD16 (seen in neutrophilia)

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4
Q

how to differentiate between AML and ALL

A

ALL is tdt+ (terminal deoxynuceltidyl transferyase)

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5
Q

distinguishing feacture of AML histologically

A

Auer rods (crystallized myeloperioxidase)

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6
Q

What syndrome increases risk of ALL and AML

A

down syndrome

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7
Q

Down syndrome after 5

A

ALL

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8
Q

Down syndrome before 5

A

AML

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9
Q

Where does ALL like to spread

A

CSF and testes

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10
Q

t(12;21)

A

better prognosis for ALL, responsive to therapy

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11
Q

t(9’22)

A

Philadelphia chromosome seen in CML (most commonly) and ALL (less commonly) poor prognosis
BCR-ABL hybrid, upregulator of TYROSINE KINASE

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12
Q

thymic mass teenager, medistinum, CD 2-8 positive

A

T ALL

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13
Q

t(15;17)

A

APML, deficient retinoic acid receptor which will lead to accumulation of promyelocytes…responds to all trans retinoic acid (m3 AML)

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14
Q

smudge cells

A

CLL

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15
Q

Richter transformation

A

CLL can transform into aggressive lymphoma (most likely diffuse large b cell lymphoma)

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16
Q

defining feature of hairy cell leukemia

A

+TRAP (tartrate resistant aci dphosphattase)….causes marrow fibrosis (dry tap) and enlargement of spleen RED PULP

17
Q

treatment for hairy cell

A

cladribine, pentostatin

adenosine deaminase inhibitor

18
Q

lytic bone lesions with hypercalcemia and cutaneous lesions

A

adult t cell lymphoma (RULE OUT MULTIPLE MYELOMA)

associated with HTLV from japan, west africa, and caribbean

19
Q

mature T cells in skin causing abscesses

A

Pautrier abscesses from mycosis fungoides

20
Q

“cerebriform nuclei” in blood

A

mycoises fungoides spreading to blood (sezary syndrome)

21
Q

basophilia

A

CML

22
Q

what antibody can help treat CML and its target

A

imantinib (CD20)

23
Q

how to differentiate between CML and leukomoid reaction from infection

A

CML cells will have a transforrmation

CML cells will be low on LAP

24
Q

JAK2 mutations

A

polycythemia vera, myelofibrosis, essential thrombocythemia

25
Q

teardrop RBCs

A

myelofibrosis (bone marrow is crying because it’s fibrosed and is a dry tap)

26
Q

how to differentiate pri,ary polycythemia vera from reactive polycythemia

A

PCV will have LOW epo

as opposed to secondary lung disease (incerease EPO to meet O2 demand) or renal cell carcinioma (exogenous EPO)

27
Q

polycythemia vera GI complication

A

)budd chiari (hypercoagulable state in hepatic vein_

28
Q

ddx painless LAD

A

lymphoma, chronic inflammation, metastatic cancer

29
Q

t(8;14)

A

Burkitt lymphoma, associated with EBV,

C-MYC

30
Q

two locations of t(8;14)

A

african burkitt - jaw

sporadic burkitt -abdomen/pelvis

31
Q

t(14;18)

A 
BCL2 overexpression (inhibits apoptosis -> uncontrolled growth)
FOLLICULAR CELL LYMPHOMA
32
Q

t(11;14)

A 
mant"11"e ce"11" "11"ymphoma
cyc11in D1(1) overexpression leads to increased phosphorylation a11ows ce11s to go from G1(1) to S phase
33
Q

t(11;18)

A

marginal cell lmyphoma
asociated with chronic imflammation (Srogen) or MALToma from h pylori
“marginally” associated with inflammation

34
Q

most common type of nonhodgkin lymphoma

A

diffuse large b cell
AGGRESSIVE!!!! and poorly differentiated
Bcl2 and Bcl6

35
Q

histologic hallmark and cell marker for hodgkin lymphoma

A

reed sternberg cells

CD15/CD30….do not express CD20 even though they involve B cells

36
Q

eosinophilia

A

mixed cellular type hodgkin lymphoma

37
Q

which hodgkin lymphoma has best and worse prognosis

A

best - lymphocyte rich

worst - lymphocyte depleted

38
Q

most common hodgkin lymphoma

A

nodular sclerosis

A_First Aid Random Memorizing (17 decks)

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