Heme/Onc 3 Flashcards
1
Q
Xeroderma pigmentosum has a deficiency in what?
A
UV-specific endonuclease
2
Q
What is the role of UV-specific endonuclease?
A
- Recognizes distortions in DNA structure caused by UV light
- Excises stretches of ssDNA which contain thymine dimer defects
3
Q
Folic acid deficiency can causes which type of anemia?
A
Megaloblastic w/in weeks
Peripheral smear:
- Macrocytosis, ovalocytosis, PMNs w/ hypersegmented nuclei (>5 lobes)
Occurs in malnutrition (think alcoholics)
4
Q
How you distinguish between B-ALL and T-ALL? Besides age of presentation (B = babies, T = teens)
A
B-ALL:
CD10+ and CD19+
T-ALL:
CD1+, CD2+, CD5+
Both are TdT+ (differentiate from AML)
5
Q
How do you differentiate between ALL and AML?
A
ALL:
TdT+, PAS (+) material
AML:
Peroxidase (+) granules, Aeur rods
