Hematology/Oncology Flashcards
Hallmark of moderate and severe factor VIII and IX deficiency
Spontaneous hemarthroses
Lumbar pain in patient receiving anticoagulation suggests:
Retroperitoneal hemorrhage
Most frequent extranodal site for lymphoma
Stomach
Greatest risk factor for pancreatic cancer
Cigarette smoking
Most common mutation seen in pancreatic ductal adenocarcinoma
KRAS (seen in virtually 100%)
Jaundice is first detectable with a bilirubin of:
2.5-3.0
Most common side effect of chemotherapy
Nausea
Proportion of persons with the disease who test positive in a screen
Sensitivity
Most common cause of renal failure in multiple myeloma
Hypercalcemia
Most common symptom in myeloma
Bone pain
Single most powerful predictor of survival in multiple myeloma
Serum B2-microglobulin
Most common clinical manifestation of sickle cell disease
Painful crises
Mainstay of therapy in sickle cell anemia with severe symptoms
Hydroxyurea (increases fetal hemoglobin)
Red cell features that characterize all forms of beta thalassemia (2)
Microcytosis, hypochromia
Alpha thalassemia in which 3 loci are deleted
HbH disease
Most common physical findings in CML
Splenomegaly
Blastic phase in CML is defined as:
Greater than or equal to 30% peripheral or marrow blasts
Accelerated blast phase is defined as:
15% or more blasts
Most specific diagnostic test for HIT
Serotonin release assay
Treatment for polycythemia Vera
Phlebotomy
Most common cause of transfusion related mortalities
TRALI
Most common neutrophil defect
Myeloperoxidase deficiency
Most common inherited bleeding disorder
VWD
Most common and earliest laboratory finding in vitamin K-deficient patients
Prolongation of PT
Mainstay of treatment for TTP
Plasma exchange
Mainstay of treatment for type 1 VWD
DDAVP (desmopressin)
Essential pathophysiologic process common to all hemolytic anemias
Increased red cell turnover
Gold standard for diagnosis of paroxysmal cold hemoglobinuria
Flow cytometry
Drug that binds to terminal complement 5, used for treatment of PNH
Eculizumab
