Hematology/Oncology

Question 1

Hallmark of moderate and severe factor VIII and IX deficiency

Answer 1

Spontaneous hemarthroses

Question 2

Lumbar pain in patient receiving anticoagulation suggests:

Answer 2

Retroperitoneal hemorrhage

Question 3

Most frequent extranodal site for lymphoma

Answer 3

Stomach

Question 4

Greatest risk factor for pancreatic cancer

Answer 4

Cigarette smoking

Question 5

Most common mutation seen in pancreatic ductal adenocarcinoma

Answer 5

KRAS (seen in virtually 100%)

Question 6

Jaundice is first detectable with a bilirubin of:

Answer 6

2.5-3.0

Question 7

Most common side effect of chemotherapy

Answer 7

Nausea

Question 8

Proportion of persons with the disease who test positive in a screen

Answer 8

Sensitivity

Question 9

Most common cause of renal failure in multiple myeloma

Answer 9

Hypercalcemia

Question 10

Most common symptom in myeloma

Answer 10

Bone pain

Question 11

Single most powerful predictor of survival in multiple myeloma

Answer 11

Serum B2-microglobulin

Question 12

Most common clinical manifestation of sickle cell disease

Answer 12

Painful crises

Question 13

Mainstay of therapy in sickle cell anemia with severe symptoms

Answer 13

Hydroxyurea (increases fetal hemoglobin)

Question 14

Red cell features that characterize all forms of beta thalassemia (2)

Answer 14

Microcytosis, hypochromia

Question 15

Alpha thalassemia in which 3 loci are deleted

Answer 15

HbH disease

Question 16

Most common physical findings in CML

Answer 16

Splenomegaly

Question 17

Blastic phase in CML is defined as:

Answer 17

Greater than or equal to 30% peripheral or marrow blasts

Question 18

Accelerated blast phase is defined as:

Answer 18

15% or more blasts

Question 19

Most specific diagnostic test for HIT

Answer 19

Serotonin release assay

Question 20

Treatment for polycythemia Vera

Answer 20

Phlebotomy

Question 21

Most common cause of transfusion related mortalities

Answer 21

TRALI

Question 22

Most common neutrophil defect

Answer 22

Myeloperoxidase deficiency

Question 23

Most common inherited bleeding disorder

Answer 23

VWD

Question 24

Most common and earliest laboratory finding in vitamin K-deficient patients

Answer 24

Prolongation of PT

Question 25

Mainstay of treatment for TTP

Answer 25

Plasma exchange

Question 26

Mainstay of treatment for type 1 VWD

Answer 26

DDAVP (desmopressin)

Question 27

Essential pathophysiologic process common to all hemolytic anemias

Answer 27

Increased red cell turnover

Question 28

Gold standard for diagnosis of paroxysmal cold hemoglobinuria

Answer 28

Flow cytometry

Question 29

Drug that binds to terminal complement 5, used for treatment of PNH

Answer 29

Eculizumab