Hematology and oncology

Question 1

Features of lead poisoning

Answer 1

“LEAD”

• lead lines on gingivae and metaphyses of long bones
• encephalopathy and erythrocyte basophilic stippling
• abdominal colic and sideroblastic anemia
• drops - wrist and foot drop. D-imercaprol and eDta as Rx

Question 2

Treatment of lead poisoning

Answer 2

Dimercaprol and EDTA

Succimer for chelation for kids “sucks to be a kid who eats lead”

Question 3

Triad of paroxysmal nocturnal hemoglobinuria

Answer 3

• Coombs negative hemolytic anemia
• Pancytopenia
• Venous thrombosis

Question 4

Treatment for paroxysmal nocturnal hemoglobinuria

Answer 4

Eculizumab (terminal complement inhibitor)

Question 5

Symptoms of acute intermittent porphyria

Answer 5

5 P’s

• Painful abdomen
• Port-wine coloured urine
• Polyneuropathy
• Psychological disturbances
• Precipitated by drugs - Cyt P450 inducers, alcohol, starvation

Question 6

Defective enzyme in acute intermittent porphyria

Answer 6

Porphobilinogen deaminase

Question 7

Defective enzyme in porphyria cutanea tarda

Answer 7

Uroporphyrinogen decarboxylase

Question 8

Subtypes of Hodgkin’s lymphoma

Answer 8

• Nodular sclerosis
• Lymphocyte rich
• Mixed cellularity
• Lymphocyte depleted

Question 9

Causes of DIC

Answer 9

STOP Making New Thrombi

• Sepsis
• Trauma
• Obstetric complications
• acute Pancreatitis
• Malignancy
• Nephrotic syndrome
• Transfusion

Question 10

Mutations of Rb linked to which CAs:

Answer 10

retinoblastoma
osteosarcoma
breast adenocarcinoma
small cell lung CA
bladder CA