Hematology Flashcards
erythrocytes
carry oxygen, concave disk, bendy and can fit through tight spaces in arteries, capillaries and veins
Rhesus (Rh) Factor
inherited protein attached to the surface of red blood cells, either positive or negative
Universal blood donor
O-
Rh positive can receive
positive or negative blood
Rh negative can only receive
negative blood
When giving blood can always give
only what they already OR less protein markers than what they have, blood won’t have anything for the body to respond
thrombocytes
clump together to achieve hemostasis; platelet plug and agglutination
Intrinsic coagulation
triggered by changes in the blood
extrinsic coagulation
triggered by something occurring outside the blood vessels (such as trauma)
Erythropoietin
produced by kidneys and stimulates production of erythrocytes
thrombopoietin
produced by spleen; controls thrombocyte production, 20% of thrombocytes are stored in the spleen, spleen breaks down old erythrocytes
clot is formed by
thrombin -> fibrinogen -> fibrin -> clot
clotting factors are produce in the
liver
anticoagulants
heparin, anti platelets, warfarin, factor Xa inhibitors
Heparin
anticoagulant; enhances antithrombim III which inhibits thrombin and prevents clots from forming; Intrinsic pathway
Heparin nursing considerations
monitor for bleeding- hematuria, hematemesis, bruising, monitor aPTT
heparin antidote
protamine sulfate
For a pt on heparin we want the aPTT to be
1.5-2x the normal
Heparin Induced Thrombocytopenia and Thrombosis (HITT)
heparin complication, occurs 5-10 days after heparin exposure, unexplained platelet drop and get clots, adverse response
HITT S&S and Tx
skin lesions at heparin injection sites, chills, fever dyspnea, chest pain, complications: DVT and PE
discontinue all heparin and start a different anticoagulant