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Internal Medicine > Hematology > Flashcards

Hematology Flashcards

1
Q

Avoid in G6PD deficiency

A

Sulfasalazine

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2
Q

Autosomal dominant disorder caused by intrinsic defects in the red cell membrane; increased MCHC.

A

Hereditary Spherocytosis

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3
Q

X-linked recessive disorder that reduces protection of RBCs from oxidative injuries, leading to hemolysis.

A

G6PD deficiency

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4
Q

Intravascular hemolysis due to increased complement-mediated RBC lysis

A

Paroxysmal Nocturnal Hemoglobinuria

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5
Q

Hemolytic anemia seen in DIC, TTP-HUS, SLE and malignant hypertension.

A

Microangiopathic Hemolytic Anemia

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6
Q

Caused by trauma to RBCs in individuals with cardiac valve prosthesis.

A

Microangiopathic Hemolytic Anemia

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7
Q

Anemia of inflammation usually associated with ?

A

Cancer related anemia aka Anemia of chronic disease

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8
Q

Lymphocytes cells commonly associated in lymphocytic leukemia?

A

B-cells

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9
Q

Treatment for Acute Promyelocytic Leukemia

A

All-trans Retinoic Acid (ATRA)

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10
Q

In iron deficiency anemia, TIBC is expected to ?
a. increased
b. decreased

A

Increased

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11
Q

In iron deficiency anemia, Serum Ferritin is expected to ?
a. increased
b. decreased

A

Decreased

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12
Q

RBC Morphology of Iron Deficiency Anemia?

A

Microcytic hypochromic

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13
Q

Most common CML mutation?

A

BCR-ABL ( Philadelphia chromosome t(9,22) )

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14
Q

General drug class used in the therapy of CML

A

Tyrosine Kinase Inhibitors ( Imatinib)

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15
Q

Electrolyte abnormality commonly seen in multiple myeloma.

A

Hypercalcemia

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16
Q

In anemia of inflammation, serum ferritin is expected to be?
a. Lower
b. Higher

A

Higher - due to decreased utilization of iron stores due to hepcidin

17
Q

This laboratory test is used to estimate bone marrow response ?

A

Reticulocyte count

18
Q

Most prominent complication of oral iron therapy

A

Gastrointestinal distress

19
Q

Triad of hemolytic anemia?

A
  1. Pallor
  2. Jaundice
  3. Splenimegaly
20
Q

Most prominent sign distinguishing hemolytic anemia from other anemias?

A

Jaundice

21
Q

Normal ABG value of pH ?

A

7.35 -7.45

22
Q

Normal ABG value of H+ ?

A

40meq/L

23
Q

Normal ABG value of pCO2 ?

A

40mmHg

24
Q

Normal ABG value of HCO3 ?

A

24meq

Internal Medicine (12 decks)

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