Hematology Flashcards
Labs in iron deficiency anemia
Iron L
Ferritin L
TIBC H
Labs in anemia of chronic disease
Iron L
Ferritin H
TIBC L
How to diagnose thalassemia
Hemoglobin electrophoresis
Treatment for thalassemia
Major thalassemia transfusion
Minor thalassemia nothing
Diagnosis of sideroblastic anemia
Ringed sideroblasts in BM bx
1st Test for G6PD
blood smear:
Bite cells and Heinz body
Best test for auto immune hemolysis
Coombs test
Best test for hereditary spherocytosis
Osmotic fragility
Splenectomy is done for which conditions
Hereditary spherocytosis
Auto-immune hemolysis
Treatment for sideroblastic anemia
B6
MMA is elevated with
B12 def
If lead is > 70ug/dL:
Hospitalization + 2 IV drugs (EDTA + Dimercaprol/British anti-lewisite)
Lead level of >45ug/dL
Start chelation therapy
Confirm diagnosis of lead poisoning
Venous lead sample
Lead poisoning screening
Capillary blood sample
Sequestration crisis labs
Low plt
Low hg
High retics
Treatment for aplastic crisis
transfusion
Treatment for sequestration crisis
transfusion
Treatment for vaso-occlusive crisis
Hydration
Sickle cell patient with new infiltration of chest
Acute chest syndrome
TTP
TheTerrible Pentad: 1- Fever 2- Neurologic 3- Renal 4- Anemia 5- Platelets (thrombocytopenia)
Cells see. In TTP
Schistiocytes
HUS
Hemolysis
Uremia
Stomach virus
Thrombocytopenia
Went to give antibiotics in HUS
Contraindicated.
ITP labs
Isolated thrombocytopenia
Chronic ITP:
Low plts for more than 12 months
Rh positove vs negative ITP
Rh negative blood patient Tx: IVIG
Rh positive blood patient Tx: Anti-D immune globulin
When to treat ITP
Plt < 10k or bleeding
Dec in ADAMTS level
TTP
Tx of vWF
Desmopressin
Hemophilia, Tx:
- Mild bleeding: Desmopressin (DDAVP)
- joint/severe bleeding: factor replacement
Bleeding time in vWF
Increased
Fanconi anemia Tx
Stem cell transplant
Triphalangeal thumb present in
Diamond blackfan anemia
Diamond blackfan anemia Tx
RBC tranfusion and steroids
ADA is high in fanconi or blackfan
Diamond blackfan anemia
Bone marrow of fanconi
Bone marrow failure