Hematology Flashcards
What is normal Hgb in women?
12-16
What is normal Hgb in men?
14-18
What is normal Hct in women?
37-47%
What is normal Hct in men?
40-54%
What is normal TIBC?
250-450
What is normal serum iron?
50-150
What is normal MCV?
80-100
Microcytic anemia is most commonly caused by what?
Iron deficiency anemia or thalassemia
Macrocytic anemia is most commonly caused by what?
B12 or folate deficiency, alcoholism, liver failure
Anemia of chronic disease causes what type of anemia?
Normocytic
Sickle cell disease causes what type of anemia?
Normocytic
What type of anemia is iron deficiency anemia?
Microcytic, hypochromic anemia
What is the leading cause of iron deficiency anemia?
Blood loss
Which anemia is characterized by having a high red cell distribution width?
Iron deficiency anemia
Low serum ferritin and high TIBC point to what?
Iron deficiency anemia
When should iron be given in relation to food?
1-2 hours after meals
Taking iron with juices high in what can increase absorption?
Vitamin C
What type of anemia is thalassemia?
Microcytic, hypochromic
What ethnicity is most likely to have thalassemia?
Asian
Are people with thalassemia minor heterozygous or homozygous for beta thalassemia?
Heterozygous
Which type of thalassemia is more common in adults?
Thalassemia minor
Which type of anemia is characterized by decreased alpha or beta hemoglobin chains?
Thalassemia
Folic acid deficiency is what type of anemia?
Macrocytic, normochromic anemia
Glossitis is typical of what types of anemia?
Folic acid and B12 deficiency
How to differentiate folic acid deficiency anemia from B12 deficiency anemia?
No neuro signs are seen with folic acid deficiency
How to treat folic acid deficiency?
Folic acid 1mg/day
What type of anemia is pernicious anemia?
Macrocytic, normochromic anemia
Cyanocobalamin is also known as what?
B12
Which anemia is most common in alcoholism?
Folic acid deficiency
Vitamin B1 is also known as what?
Thiamine
What type of anemia is anemia of chronic disease?
Normocytic and normochromic
How is anemia of chronic disease managed?
By treating the associated disease
How do you manage sickle cell crisis?
Fluids, pain meds and O2
What is Von Willebrand disease?
Genetic disorder resulting in reduced ability to create blood clots
Which clotting factor is affected in Von Willebrand?
Factor VIII
How is Von Willebrand disease managed?
With desmopressin
Most leukemia in adults is what type?
Chronic lymphocytic anemia
What is the hallmark of acute lymphocytic leukemia?
Pancytopenia with circulation blasts
What is the hallmark of chronic lymphocytic anemia?
Lymphocytosis
What is the hallmark of chronic myelogenous leukemia?
Philadelphia chromosome
How is a diagnosis of leukemia confirmed?
Bone marrow aspiration
How is leukemia managed?
Chemo and bone marrow transplantation
Incidence of tumor lysis syndrome can be reduced with which drug?
Allopurinol
What is the difference between stage II and stage III lymphoma?
Stage II involves lymph nodes on one side of the diaphragm; stage III involves lymph nodes on both sides of the diaphragm
What type of cells differentiate Hodgkin’s lymphoma from non-Hodgkin’s?
Reed-Sternberg cells (occur in Hodgkin’s)
Is radiation used for leukemia or lymphoma?
Lymphoma
What is a normal platelet value?
150,000-400,000
What is the platelet count in DIC?
Less than 150,000
What is fibrinogen in DIC?
Less than 170 mg/dl
What is FDPs (fibrin degradation products) in DIC?
Greater than 45
What is PT in DIC?
Greater than 19 seconds
What is PTT in DIC?
Greater than 42 seconds
What three things to give for DIC?
Platelet transfusions, FFP, and cryoprecipitate
What else must be given if RBCs are being transfused in large amounts?
FFP
What does cryoprecipitate do in DIC?
Maintains fibrinogen levels
What does FFP do?
Replaces clotting factors