Hema

Question 1

Physiologic anemia of infancy usualy lasts for how many weeks?

Answer 1

8-12

Question 2

Physiologic anemia of prematurity has hemoglobin levels of

Answer 2

7-9 g/dl

Question 3

Does physiologic anemia of prematurity require treatment?

Answer 3

Yes EPO or transfusion

Question 4

Most important sign of iron deficiency anemia

Answer 4

Pallor

Question 5

Expected rise in hemoglobin per day after iron treatment

Answer 5

0.1-0.4 g/dl

Question 6

Treatment for IDA

Answer 6

Elemental iron

3-6mg/kg/day

Question 7

After treatment of IDA, Repeat CBC should be done after

Answer 7

4 weeks

Question 8

Target cells
Heinz bodies
Decreased retic count
Normal RDW

Answer 8

Thalassemia

Question 9

Definitive diagnosis of thalassemia can be done through

Answer 9

Hb electrophoresis

Question 10

This infection should be watched out for in thalassemia because it eats up the free iron

Answer 10

Yersinia enterocolitica

Question 11

Tachycardia and splenomegaly

Increased reticulocyte and MCHC normal platelet count

Answer 11

Spherocytosis

Question 12

Defect in spectrin or ankyrin
Osmotic fragility test
Increased MCHC, retic count
Normal MCV

Answer 12

Spherocytosis

Question 13

Vasoocclusive crisis
Autosomal recessive
Crew cut or hair on end appearance of skull in xray
Howell Jolly bodies

Answer 13

Sickle cell anemia

Question 14

Treatment for sickle cell

Answer 14

Hydration and analgesia for acute crises

Question 15

Most common hereditary bleeding disorder

Answer 15

vWD

Question 16

Most common and most serious congenital coagulation factor deficiency?

Answer 16

Hemophilia A

Question 17

Most common hereditary hypercoagulable disorder?

Answer 17

Factor V Leiden

Question 18

Hallmark of hemophilia

Answer 18

Prolonged bleeding

Question 19

Earliest joint hemorrhage in children

Answer 19

Ankles

Question 20

Treatment for mild von willebrand disease type 1

Answer 20

Desmopressin

Question 21

Laboratory finding in hemophilia

Answer 21

Increased PTT

Question 22

Laboratory finding in vWD

Answer 22

Increased PTT and bleeding time

Question 23

Laboratory finding in ITP

Answer 23

Increased bleeding time

Decreased platelet

Question 24

Laboratory finding in vitamin K deficiency

Answer 24

Increased PT

Question 25

Laboratory finding in DIC

Answer 25

Decreased platelet count | Increased PT PTT bleeding time

Question 26

What type of leukemia in childhood will have the best response to chemotherapy?

Answer 26

ALL

Question 27

Site of relapse of ALL

Answer 27

bone marrow CNS Testes

Question 28

Site of spread of ALL

Answer 28

Liver Spleen Lymph nodes

Question 29

``` <2 years >10 years old Male WBC >100,000 on presentation CNS involvement Mediastinal mass ``` Poor prognostic factors of what disease

Answer 29

ALL

Question 30

Renal tumor of embryonal origin

Answer 30

Wilms tumor

Question 31

Painless abdominal enlargement with flank mass that DOES NOT cross the midline

Answer 31

Wilms

Question 32

Drug of choice for PCP prophylaxis in children with ALL undergoing chemotherapy is

Answer 32

Co-trimoxazole

Question 33

Embryonic tumor of neural crest origin

Answer 33

Neuroblastoma

Question 34

Most common site where neuroblasts migrate

Answer 34

Sympathetic ganglia and adrenals

Question 35

Differential diagnosis of small, round, blue cell tumors WARMER PN

Answer 35

``` Wilms Acute leukemia Rhabdomyosarcoma Mesothelioma/medulloblastoma Ewing sarcoma Retinoblastoma Primitive neuroectodermal tumor (PNET) Neuroblastoma ```

Question 36

Associated with: Neurofibromatosis Beckwith- Weidemann syndrome WAGR syndrome

Answer 36

Wilms tumor

Question 37

``` Associated with: N-myc oncogene Neurofibromatosis Hirschprung Tuberous sclerosis Pheochromocytoma ```

Answer 37

Neuroblastoma

Question 38

``` Horner syndrome Abdominal mass that MAY cross the midline Cord compression Racoon eyes Dancing eyes and feet ```

Answer 38

Neuroblastoma

Question 39

Diagnosis for neuroblastoma

Answer 39

Urine VMA and HVA Abdominal CT Bone marrow aspirate

Question 40

``` Long bones and skull BM Liver LN Skin ``` Most common metastatic sites of

Answer 40

Neuroblastoma

Question 41

What are the B symptoms of | Lymphoma?

Answer 41

High grade fever Weight loss Night sweats

Question 42

``` Regional lymphadenopathy Chemotherapy Bimodal age distribution EBV, CMV, HHV 6 Reed Sternberg cells Contiguous LN spread ```

Answer 42

Hodgkin lymphoma

Question 43

Hodgkin lymphoma type that has the Best prognosis

Answer 43

Mixed cellularity lymphocyte predominant

Question 44

``` Systemic adenopathy Radiation for CNS involvement Chemotherapy 60% of lymphomas in chidren and adolescent EBV- Burkitt Non contiguous LN spread ```

Answer 44

Non-Hodgkin

Question 45

Results from failure or autoimmune destruction of myeloid stem cells

Answer 45

Aplastic anemia

Question 46

Most likely cause of aplastic anemia

Answer 46

Idiopathic

Question 47

Typical PBS finding in aplastic anemia

Answer 47

Hypocellularity and pancytopenia

Question 48

Aplastic anemia with microcephaly, microphthalmia, hearing loss and limb anomalies

Answer 48

Fanconi anemia