Heamatological Changes In Preganancy

Question 1

Haematology Al changes in pregnancy include

Answer 1

Physiologic anemia
Prothrombotic changes
Increased plasma volume
Mild neutrophilia

Question 2

Plasma volume increase in first 6-12 was of pregnancy

Answer 2

10-15%

Question 3

Plasma volume expands up to what week before it begins to plateau

Answer 3

30-34 wks

Question 4

Total gain at term

Answer 4

1.1-1.2L

Question 5

Plasma volume at term

Answer 5

4.7-5.2

30-50% above non pregnant woman

Question 6

Sodium and water retained with increased plasma volume

Answer 6

1000meq sodium

6-8 L of water

Question 7

What causes increase in plasma volume

Answer 7

A response to underfilled vascular system caused by

Systemic Vasodilation
Increase vascular capacitance
Plasma renin increases
Atrial natriuretic peptide levels reduced
High hydration from mother
High colloid oncotic pressure

Question 8

Red blood cell mass increases at

Answer 8

8-10 wks

20-30% higher than non pregnant women at end of gestation

Question 9

MCV in pregnancy

Answer 9

Increases due to increase in RBC volume

Question 10

Why anemia in pregnancy

Answer 10

Increase in plasma volume far greater than increase in RBC

Question 11

Erythropoietin levels

Answer 11

Increase by 50%

Question 12

When does neutrophil count begin to increase

Answer 12

2nd month of pregnancy

Question 13

When does WBC count plateau

Answer 13

2 to 3 trimester and ranges from 9000-15000

Question 14

Metalocytes and my elicited

Answer 14

Small number seen in peripheral circulation

Question 15

In WBC are found

Answer 15

Doyle bodies

Blue staining cytoplasmic inclusions

Question 16

The absolute lymphocyte count and T and B lymphocytes

Answer 16

Do not change

Question 17

Monocyte count

Answer 17

Stable

Question 18

Basophil count

Answer 18

Decrease slightly

Question 19

Eosinophil count

Answer 19

Increase slightly

Question 20

Platelet count

Answer 20

Declines as pregnancy progresses but still in non pregnant range 150,000-450000

Question 21

Cause of decline in platelet count

Answer 21

Gestational thrombocytopenia

Question 22

Prothrombotic state in pregnancy

Answer 22

Prevents excess haemorrhage in placental seperation

Question 23

Prothrombotic state and increase in coagulation factors risk

Answer 23

Thromboembolism

Question 24

PAI-1 levels

Answer 24

Increase

Is derived from placenta and decidua

Question 25

Factor 8 levels

Answer 25

Decrease in 2-3 trimester

Question 26

APTT in pregnancy

Answer 26

Normal range

Shortens near term

Question 27

PT

Answer 27

Shortens

Question 28

D dimer diagnosis of TE

Answer 28

Cannot since it increases in pregnancy

Question 29

Hbf affinity for oxygen

Answer 29

High affinity
O-Hb dissociation Curve shifts to the left
2,3 bpg binds less strongly to Hbf

Question 30

Arterial O pressures in neonates

Answer 30

Reduced

19mmHg as compared to 27 mmHg in adults

Question 31

Normal neonatal hb

Answer 31

18-20g/dl

Question 32

Uremic plasma expresses this on RBC

Answer 32

Phosphatidyl serine in order to be recognized by macrophage

Question 33

Erythropoietin levels can affect

Answer 33

Platelet levels bc of its relation to thrombopoietin

Question 34

Erythropoietin potentiates the effect of

Answer 34

Megakaryocyte colony stimulating factors acetylhydroase paraxoase