Acquired bleeding disorders Flashcards
Most prevalent between acquired and inherited coagulation disorders
Acquired more common than inherited
How many coagulation factors are affected in acquired coagulation disorders
More than 1
Classification of acquired coagulation disorders
Deficiency of vitamin k liver function related Antibody induced Drug/transfusion induced Interference from abnormal proteins Consumptive coagulopathy
Why will a deficiency of vitamin k cause coagulation disorders
This is because some coagulation factors are vitamin k dependant
How does poor liver function cause coagulation disorders
This is because a lot of coagulation factors are produced in the liver.
Hepatitis, cirrhosis, hepatocellular ca etc
How do antibodies cause coagulation disorders
Antibodies can be produced against certain factors necessary for coagulation
Vitamin K is important in the synthesis of these coagulation factors
factor 2, 7,9, 10
which are important factors in all the pathways, hence without it none of the pathways can function
Sources of vitamin k
green vegetables, bacterial synthesis in the gut
In what circumstances does vitamin k deficiency occur
Newborn
Biliary obstruction
Malabsorption
Inhibition of vitamin k
Why does vitamin K deficiency occur in the newborn
Newborn does not eat green vegetables, and their gut is not well developed to synthesize vitamin k
Breast milk contains low amount of vitamin k
Causes of malabsorption syndrome
surgery, tropical sprue, gluten sensitive enteropathy
warfarin and vitamin k
warfarin is a vitamin k antagonist
The abscence of vitamin k leads to the production of
PIVKA. Protein induced in vitamin k absence which in themselves lead to a bleeding tendency
Antibodies being produced against certain factors may be
Induced or spontaneous
Von willebrands disease is
Autoimmune with antibodies being produced against von willebrands factor
